|
Parkinson Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the rs1611115 and rs1108580 did not show association with PD; plasma DBH activity was not significantly different between patients and controls (p-value > 0.05).
|
31082450 |
2019 |
|
Parkinson Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the DBH rs1611115 genetic polymorphism might not be associated with PD.
|
30187307 |
2018 |
|
Parkinson Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
CONCLUSIONS DBH rs1611115 polymorphism was likely to be associated with the susceptibility to PD, but we did not find that rs732833 is a susceptibility marker for PD.
|
27177268 |
2016 |
|
Parkinson Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
A highly significant association of dopamine beta-hydroxylase (DBH) haplotypes (rs1611115T>C - rs1108580A>G - rs5320A>G - rs129882C>T) with PD was observed; haplotypes C-A-G-C [P=0.000005, Odds ratio (95% confidence interval): OR (95% CI)=1.76 (1.38-2.25)] and C-A-G-T [P=0.000001, OR (95% CI)=0.49 (0.37-0.65)] retaining significance after Bonferroni correction. rs129882, a 3'UTR SNP in DBH showed significant association with disease severity [Hoehn and Yahr (P=0.005) and Unified Parkinson Disease Rating Scale (P=0.006)].
|
20498626 |
2010 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
COMT Val158Met (rs4680), DBH rs1611115 (also called -1021C/T or -970C/T), and MAOB rs1799836 (also called A644G) polymorphisms have been previously associated with AD.
|
31771069 |
2020 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
While the DBH polymorphism (rs1611115) was also associated with increased AD risk (OR = 1.1, p = 0.04) the synergistic interaction (SF = 2.2, p = 0.007) between BDNF (rs6265) and DBH (rs1611115) contributed greater AD risk than either gene alone, an effect that was greater in women (SF = 2.4, p = 0.04) than men (SF = 2.0, p = 0.2).
|
30909233 |
2019 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD.
|
21070631 |
2010 |
|
Hepatolenticular Degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three polymorphisms of DBH (rs1611115 in the promoter, rs1108580 in exon 2 and rs129882 in 3'-UTR) were screened for their association with the clinical attributes (hepatic and neurological features) and age of onset of WD using a polymerase chain reaction-restriction fragment length polymorphsm method and sequencing approach.
|
31265749 |
2019 |
|
Cognition Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study examines the association of plasma DβH (pDβH) activity, DBH gene polymorphisms (-1021C>T, rs1611115 and 444G>A, rs1108580) and cognitive deficits in Han Chinese patients with schizophrenia.
|
28647493 |
2018 |
|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study examines the association of plasma DβH (pDβH) activity, DBH gene polymorphisms (-1021C>T, rs1611115 and 444G>A, rs1108580) and cognitive deficits in Han Chinese patients with schizophrenia.
|
28647493 |
2018 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings confirm a strong association between genotype at rs1611115 and pDβH activity in Chinese patients with schizophrenia.
|
28647493 |
2018 |
|
Marijuana Abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that individuals with low activity DBH genotypes (rs1611115 CT/TT) are more sensitive to the influence of cannabis and cocaine on cognitive impulse control and functional connectivity in the limbic 'reward' circuit because they experience a drug induced hyperdopaminergic state compared to individuals with high activity DBH genotypes (rs1611115 CC).
|
26667034 |
2016 |
|
Gambling, Pathological
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigate the influence of rs1611115 on the neural correlates of emotional and motivational processing in PG and healthy comparison (HC) participants.
|
27194378 |
2016 |
|
Addictive Behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Dopamine beta-hydroxylase (DBH) converts dopamine to norepinephrine; the T allele of a functional single-nucleotide polymorphism rs1611115 (C-1021T) in the DBH gene is associated with less DBH activity and has been linked to emotional processes and addiction.
|
27194378 |
2016 |
|
Angina Pectoris
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor alleles of rs1611115 and rs1108580 were associated with sympathetic phenotypes, including angina pectoris.
|
25326128 |
2014 |
|
Cocaine Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study.
|
24809448 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs1611115 (near 5') C-allele and related haplotypes were significantly associated with alcohol dependence in females.
|
23906995 |
2013 |
|
Epilepsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stage 1 analysis included 290 patients with epilepsy and revealed a higher load of adverse psychotropic side effects of LEV in patients carrying genetic variants associated with decreased dopaminergic activity: rs1611115 (dopamine-β-hydroxylase, DBH), rs4680 (catechol-O-methyltransferase, COMT), and rs1800497 (dopamine receptor D2-associated ANKK1 TAQ-1A).
|
22881836 |
2013 |
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
-1021C>T (rs1611115) polymorphism in promoter region, 444G>A (rs1108580) polymorphism in exon 2 and 1603C>T (rs6271; C535R) polymorphism in exon11 of DBH gene were analyzed in 106 patients with bipolar disorder and 106 healthy subjects by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.
|
23384717 |
2013 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, we aimed to look for association of functional variants in ANKK1 (rs1800497), DRD2 (rs6275 and rs1799732) and DBH (rs7239728 and rs1611115) genes with migraine susceptibility.
|
22875483 |
2013 |
|
Attention deficit hyperactivity disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gene-gene interaction analysis revealed significant additive effect of DBH rs1108580 and DRD4 rs1800955 with significant main effects of DRD4 exon3 VNTR, DAT1 3'UTR and intron 8 VNTR, MAOA u-VNTR, rs6323, COMT rs4680, rs362204, DBH rs1611115 and rs1108580 thereby pointing towards a strong association of these markers with ADHD.
|
21216270 |
2011 |