rs16906252, MGMT

N. diseases: 19
Disease: Childhood Glioblastoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Childhood Glioblastoma
CUI: C0280474
Disease: Childhood Glioblastoma
0.020 GeneticVariation BEFREE The T allele of the rs16906252 SNP is a key determinant in the acquisition of MGMT methylation in glioblastoma. 25910840 2015
Childhood Glioblastoma
CUI: C0280474
Disease: Childhood Glioblastoma
0.020 GeneticVariation BEFREE More interestingly, our study demonstrated that a promoter variant, the c.-56C>T (rs16906252) single nucleotide polymorphism (SNP) located within a cis-acting enhancer element at the proximal end of MGMT, is associated with the presence of MGMT promoter methylation in de novo glioblastoma. 22975219 2013