We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis.
The subgroup analysis stratified by ethnicity showed a weak association between the IL-1<i>β</i> polymorphism (rs16944</span>) and chronic periodontitis in the Caucasian population (recessive model, OR = 1.34, 95% CI = 1.017-1.758, <i>P</i> = 0.037).
Seventy-four patients with VD of whom 36 had CP were genotyped for single nucleotide polymorphisms in the IL1A -889 (rs1800587), IL1B +3954 (rs1143634) and IL1B at -511 (rs16944) genes and for VNTR polymorphisms in the IL1RN gene.