|
Endometriosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This might constitute the first step towards identifying polymorphism combinations that predispose to endometriosis (IFNG (CA) repeat, GSTM1 null genotype, GSTP1 rs1695, WNT4 rs16826658 and WNT4 rs2235529) in a large cohort of patients with well-defined inclusion criteria.
|
31821471 |
2020 |
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Herein, we investigated the relationship of three GSTs polymorphisms (GSTT1 deletion, GSTM1 deletion, GSTP1 rs1695) as well as GSTP1 promoter region DNA methylation and HCC risk with a particular focus on the interaction with OCPs exposure among 90 HCC cases and 99 controls in a Chinese population.
|
31731000 |
2020 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Influence of DPYD*9A, DPYD*6 and GSTP1 ile105val Genetic Polymorphisms on Capecitabine and Oxaliplatin (CAPOX) Associated Toxicities in Colorectal Cancer (CRC) Patients.
|
31653159 |
2019 |
|
Thrombocytopenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
No significant association was found between DPYD*6, GSTP1 ile105val polymorphisms and CAPOX related toxicities except for thrombocytopenia.
|
31653159 |
2019 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Otherwise, the combination of <i>GSTM1</i> entire gene deletion and (GG) genotype of <i>GSTP1</i> polymorphism (rs1695) was significantly associated with BC with p-value <0.05 (i.e. p-value was not significant after correcting for multiple comparison).
|
31571925 |
2019 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Otherwise, the combination of <i>GSTM1</i> entire gene deletion and (GG) genotype of <i>GSTP1</i> polymorphism (rs1695) was significantly associated with BC with p-value <0.05 (i.e. p-value was not significant after correcting for multiple comparison).
|
31571925 |
2019 |
|
Carcinoma of bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
Glutathione S-Transferase Pi 1 (GSTP1) Gene 313 A/G (rs1695) polymorphism is associated with the risk of urinary bladder cancer: Evidence from a systematic review and meta-analysis based on 34 case-control studies.
|
31454540 |
2019 |
|
Malignant neoplasm of urinary bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
Glutathione S-Transferase Pi 1 (GSTP1) Gene 313 A/G (rs1695) polymorphism is associated with the risk of urinary bladder cancer: Evidence from a systematic review and meta-analysis based on 34 case-control studies.
|
31454540 |
2019 |
|
TARSAL-CARPAL COALITION SYNDROME
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study indicated that GSTP1 gene 313 A/G (rs1695) polymorphism increased the susceptibility to BCa, particularly to TCC.
|
31454540 |
2019 |
|
Heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, carriers of at least one variant <i>GSTP1</i>∗Val (rs1695) allele were at 1.7-fold increased HF risk than <i>GSTP1</i>∗Ile/Ile carriers (<i>p</i> = 0.031), which was higher when combined with the variant <i>GSTA1</i>∗B allele (OR = 2.2, <i>p</i> = 0.034).
|
31275451 |
2019 |
|
Congestive heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, carriers of at least one variant <i>GSTP1</i>∗Val (rs1695) allele were at 1.7-fold increased HF risk than <i>GSTP1</i>∗Ile/Ile carriers (<i>p</i> = 0.031), which was higher when combined with the variant <i>GSTA1</i>∗B allele (OR = 2.2, <i>p</i> = 0.034).
|
31275451 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
|
0.050 |
GeneticVariation
|
BEFREE |
GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms in outcomes of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation.
|
31249357 |
2019 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variant alleles found to increase the risk of developing TCa were CYP1A1*2C (rs1048943), GSTP1 (rs169</span>5), and GSTT1null, especially when in conjunction with a cance</span>r family history and/or a smoking habit.
|
31107374 |
2019 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variant alleles found to increase the risk of developing TCa were CYP1A1*2C (rs1048943), GSTP1 (rs169</span>5), and GSTT1null, especially when in conjunction with a cance</span>r family history and/or a smoking habit.
|
31107374 |
2019 |
|
Malignant neoplasm of testis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of the multivariate analysis showed that the presence of variant alleles of GSTP1 (rs1695) together with a smoking habit and a family history of cancer accounted for a 15.9% risk of developing TCa in the Chilean population.
|
31107374 |
2019 |
|
Malignant Testicular Germ Cell Tumor
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of the multivariate analysis showed that the presence of variant alleles of GSTP1 (rs1695) together with a smoking habit and a family history of cancer accounted for a 15.9% risk of developing TCa in the Chilean population.
|
31107374 |
2019 |
|
Malignant Head and Neck Neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
A cost-minimization analysis was planned to compare GSTP1 c.313A>G genotyping versus overall fosaprepitant implementation for patients with head and neck cancer under chemoradiation therapy with high-dose cisplatin.
|
30870506 |
2019 |
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A cost-minimization analysis was planned to compare GSTP1 c.313A>G genotyping versus overall fosaprepitant implementation for patients with head and neck cancer under chemoradiation therapy with high-dose cisplatin.
|
30870506 |
2019 |
|
Vomiting
|
|
0.010 |
GeneticVariation
|
BEFREE |
GSTP1 c.313A>G genotype was recently described as a predictor of vomiting related to high-dose cisplatin.
|
30870506 |
2019 |
|
Nausea and vomiting
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cost-minimization analysis of GSTP1c.313A>G genotyping for the prevention of cisplatin-induced nausea and vomiting: A Bayesian inference approach.
|
30870506 |
2019 |
|
Nausea
|
|
0.010 |
GeneticVariation
|
BEFREE |
GSTP1 c.313A>G genotyping may reduce the use of preventive support for chemotherapy induced nausea and lower the overall cost of treatment.
|
30870506 |
2019 |
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
There are several meta-analyses on the genetic relationship between the rs1695 polymorphism within the GSTP1 (glutathione S-transferase pi 1) gene and the risk of different SCC (squamous cell carcinoma) diseases, such as ESCC (oesophageal SCC), HNSCC (head and neck SCC), LSCC (lung SCC), and SSCC (skin SCC).
|
30665373 |
2019 |
|
Thrombocytopenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of the study is to evaluate the association between granulocytopenia and thrombocytopenia induced by platinum-based drugs and GSTP1 rs1695 gene polymorphism by meta-analysis.
|
30238837 |
2018 |
|
Agranulocytosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the GSTP1 rs1695 gene polymorphism is associated with granulocytopenia induced by platinum-based drugs.
|
30238837 |
2018 |
|
Granulocytopenic disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the GSTP1 rs1695 gene polymorphism is associated with granulocytopenia induced by platinum-based drugs.
|
30238837 |
2018 |