|
Acoustic Neuroma
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was evidence of supermultiplicativity of the joint effect of GSTP1 I105V and CYP2E1 RsaI variants on both glioma and acoustic neuroma, even following adjustment of estimates toward a common prior distribution using hierarchical regression models.
|
12540498 |
2003 |
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Role of GSTM1 (Present/Null) and GSTP1 (Ile105Val) polymorphisms in susceptibility to acute lymphoblastic leukemia among the South Indian population.
|
19256768 |
2009 |
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
A combination between GSTM1 double-null genotype and rs1695 also showed an association with ALL (P=0.042).
|
27299594 |
2016 |
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Sixteen single nucleotide polymorphisms (SNPs) (CYP3A4*1B A>G, CYP3A5*3 G>A, GSTP1 313 A>G, GSTM1 deletion, GSTT1 deletion, MDR1 exon 21 G>T/A, MDR1 exon 26 C>T, MTHFR 677 C>T, MTHFR 1298 A>C, NR3C1 1088 A>G, RFC 80 G>A, TPMT 238 G>C, TPMT 460 G>A, TPMT 719 A>G, VDR intron 8 G>A, VDR FokI T>C) that have been implicated in the pharmacogenetics of ALL therapy were analyzed by TotalPlex amplification and SNP genotyping.
|
18385010 |
2008 |
|
Acute pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of GSTM1 is associated with increased susceptibility for AP, and the GSTP1 Val105Ile SNP is associated with an increased risk for AP in men.
|
27984487 |
2017 |
|
Adenocarcinoma of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma.
|
12010858 |
2002 |
|
Adenoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used a case-control study design (234 carcinomas, 229 high-risk adenomas, 762 low-risk adenomas and 400 controls) to test the association between dietary factors (meat versus fruit, berries and vegetables) genetic polymorphisms in biotransformation genes (GSTM1, GSTT1, GSTP1 Ile105Val, EPHX1 Tyr113His and EPHX1 His139Arg), and risk of colorectal carcinomas and adenomas.
|
18093316 |
2007 |
|
Adenoma of large intestine
|
|
0.020 |
GeneticVariation
|
BEFREE |
The GSTM1 and GSTT1 deletion polymorphisms, and the single nucleotide polymorphisms in GSTP1 (A313G) and in GSTA1 (C-69T) were assessed among 746 cases who developed colorectal adenomas and 698 endoscopy-based controls without any type of colorectal polyps.
|
16365014 |
2005 |
|
Adenoma of large intestine
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future.
|
22161138 |
2012 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
A combination between GSTM1 double-null genotype and rs1695 also showed an association with ALL (P=0.042).
|
27299594 |
2016 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Sixteen single nucleotide polymorphisms (SNPs) (CYP3A4*1B A>G, CYP3A5*3 G>A, GSTP1 313 A>G, GSTM1 deletion, GSTT1 deletion, MDR1 exon 21 G>T/A, MDR1 exon 26 C>T, MTHFR 677 C>T, MTHFR 1298 A>C, NR3C1 1088 A>G, RFC 80 G>A, TPMT 238 G>C, TPMT 460 G>A, TPMT 719 A>G, VDR intron 8 G>A, VDR FokI T>C) that have been implicated in the pharmacogenetics of ALL therapy were analyzed by TotalPlex amplification and SNP genotyping.
|
18385010 |
2008 |
|
Adult Glioblastoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of Glutathione S-Transferase P-1 (GSTP-1) rs1695 polymorphism with overall survival in glioblastoma patients treated with combined radio-chemotherapy.
|
28965273 |
2018 |
|
Adult Glioblastoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We examined GSTP1 Ile105Val polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma samples.
|
21128213 |
2010 |
|
Adult Hodgkin Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The GSTP1 Ile(105)Val polymorphism was associated in a dose-dependent fashion with an improved failure-free survival in patients with Hodgkin's lymphoma (P = 0.02).
|
15788664 |
2005 |
|
Adult Hodgkin Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The GSTP1 rs1695 A-allele reduced the risk for HL (GG vs. AG, OR 0.64 [0.42-0.99], p = 0.04; GG vs. AG/AA combined genotypes, OR 0.70 [0.47-1.04], p = 0.07), and the GSTT1 deleted genotype increased the risk for HL (OR 3.17 [1.97-5.09], p < 0.001) regardless of age.
|
22475179 |
2012 |
|
Adult Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Pooled results showed that the GSTT1 null polymorphism might increase the risk of lymphoma (odds ratio [OR] 2.26, 95% confidence interval [CI] 1.20, 4.24; p = 0.01; random-effects model), whereas the impact of GSTM1 and GSTP1 Ile105Val polymorphisms was not significant.
|
22734843 |
2013 |
|
Adult Myelodysplastic Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphism of GSTM1, GSTT1 and GSTP1 Ile105Val was investigated in a case-control study in a Hungarian patient population comprising 86 patients with myelodysplastic syndrome and 99 hospital-based controls.
|
18493876 |
2008 |
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that the GSTP1 variant rs1695 moderately increases the risk of exudative AMD.
|
22487578 |
2012 |
|
Agenesis of corpus callosum
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study is to investigate the association of GSTP1 Ile105Val genetic polymorphism with oxaliplatin efficacy and toxicity in advanced colorectal cancer (ACC) patients.
|
19084393 |
2009 |
|
Agranulocytosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the GSTP1 rs1695 gene polymorphism is associated with granulocytopenia induced by platinum-based drugs.
|
30238837 |
2018 |
|
Alzheimer Disease, Late Onset
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G polymorphisms and the risk of AD in an Iranian population.
|
29072550 |
2018 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Higher frequencies of the mutant genotypes were observed in AD patients (13% for both A313G and C341T) when compared with control subjects (7% for A313G and 8% for C341T), but association of GSTP1 GG (OR 2.057, 95% CI 0.796-5.315, p=0.094) and TT (OR 1.691, 95% CI 0.669-4.270, p=0.514) genotypes with an increased risk of AD was not confirmed by statistical analysis.
|
15080568 |
2004 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
GSTM1 null genotype and GSTP1 Ile105Val polymorphism are associated with increased risk of Alzheimer's disease.
|
25633095 |
2016 |
|
Anemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, a significant association of GSTP1 I105V genotype with severe malarial anemia was discovered (26.0% against 10.3% mild malaria, P = 0.004).
|
19635899 |
2009 |
|
Anemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
In single-locus analysis, Ile/Val and Ile/Val+Val/Val genotypes of the GSTP1 Ile105Val (rs1695) polymorphism reached statistical significance with grade 2-4 anemia (P=0.019, P=0.027).
|
23812950 |
2013 |