rs1695, GSTP1

N. diseases: 188
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma
CUI: C0007137
Disease: Squamous cell carcinoma
0.010 GeneticVariation BEFREE There are several meta-analyses on the genetic relationship between the rs1695 polymorphism within the GSTP1 (glutathione S-transferase pi 1) gene and the risk of different SCC (squamous cell carcinoma) diseases, such as ESCC (oesophageal SCC), HNSCC (head and neck SCC), LSCC (lung SCC), and SSCC (skin SCC). 30665373 2019
Heart failure
CUI: C0018801
Disease: Heart failure
0.010 GeneticVariation BEFREE However, carriers of at least one variant <i>GSTP1</i>∗Val (rs1695) allele were at 1.7-fold increased HF risk than <i>GSTP1</i>∗Ile/Ile carriers (<i>p</i> = 0.031), which was higher when combined with the variant <i>GSTA1</i>∗B allele (OR = 2.2, <i>p</i> = 0.034). 31275451 2019
Congestive heart failure
CUI: C0018802
Disease: Congestive heart failure
0.010 GeneticVariation BEFREE However, carriers of at least one variant <i>GSTP1</i>∗Val (rs1695) allele were at 1.7-fold increased HF risk than <i>GSTP1</i>∗Ile/Ile carriers (<i>p</i> = 0.031), which was higher when combined with the variant <i>GSTA1</i>∗B allele (OR = 2.2, <i>p</i> = 0.034). 31275451 2019
Nausea
CUI: C0027497
Disease: Nausea
0.010 GeneticVariation BEFREE GSTP1 c.313A>G genotyping may reduce the use of preventive support for chemotherapy induced nausea and lower the overall cost of treatment. 30870506 2019
Nausea and vomiting
CUI: C0027498
Disease: Nausea and vomiting
0.010 GeneticVariation BEFREE Cost-minimization analysis of GSTP1c.313A>G genotyping for the prevention of cisplatin-induced nausea and vomiting: A Bayesian inference approach. 30870506 2019
Vomiting
CUI: C0042963
Disease: Vomiting
0.010 GeneticVariation BEFREE GSTP1 c.313A>G genotype was recently described as a predictor of vomiting related to high-dose cisplatin. 30870506 2019
Malignant neoplasm of testis
CUI: C0153594
Disease: Malignant neoplasm of testis
0.010 GeneticVariation BEFREE The results of the multivariate analysis showed that the presence of variant alleles of GSTP1 (rs1695) together with a smoking habit and a family history of cancer accounted for a 15.9% risk of developing TCa in the Chilean population. 31107374 2019
Malignant Testicular Germ Cell Tumor
0.010 GeneticVariation BEFREE The results of the multivariate analysis showed that the presence of variant alleles of GSTP1 (rs1695) together with a smoking habit and a family history of cancer accounted for a 15.9% risk of developing TCa in the Chilean population. 31107374 2019
TARSAL-CARPAL COALITION SYNDROME
CUI: C1861305
Disease: TARSAL-CARPAL COALITION SYNDROME
0.010 GeneticVariation BEFREE This study indicated that GSTP1 gene 313 A/G (rs1695) polymorphism increased the susceptibility to BCa, particularly to TCC. 31454540 2019
Agranulocytosis
CUI: C0001824
Disease: Agranulocytosis
0.010 GeneticVariation BEFREE In conclusion, the GSTP1 rs1695 gene polymorphism is associated with granulocytopenia induced by platinum-based drugs. 30238837 2018
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.010 GeneticVariation BEFREE The purpose of this case-control study was to investigate the possible role of GSTM1 and GSTT1 deletion polymorphisms, and Single Nucleotide Polymorphism (SNP), GSTP1 313 A > G (Ile105Val), in DN susceptibility. 29981844 2018
Gastritis, Atrophic
CUI: C0017154
Disease: Gastritis, Atrophic
0.010 GeneticVariation BEFREE There is a multifarious interaction between the DNA repair gene <i>ERCC5</i> SNPs (rs2094258 and rs873601) and the metabolic gene <i>GSTP1</i> rs1695, which may form the basis for various inter-individual susceptibilities to AG. 29434449 2018
Rhinitis
CUI: C0035455
Disease: Rhinitis
0.010 GeneticVariation BEFREE To evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A (rs2275913) and GSTP1 (rs1695) genes are associated with rhinitis and/or asthma in adults of Portuguese ancestry. 27561723 2018
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.010 GeneticVariation BEFREE We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G polymorphisms and the risk of AD in an Iranian population. 29072550 2018
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.010 GeneticVariation BEFREE Logistic regression analysis of the data revealed the null genotype of GSTM1 and the GG genotype of the GSTP1 (313A/G) gene were associated with an approximately twofold enhanced risk of developing CAD, whereas GSTT1(-) plays a defensive role against CAD development in north Indians. 30039864 2018
Pneumonitis
CUI: C3714636
Disease: Pneumonitis
0.010 GeneticVariation BEFREE GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study. 29556330 2018
Granulocytopenic disorder
CUI: C4551627
Disease: Granulocytopenic disorder
0.010 GeneticVariation BEFREE In conclusion, the GSTP1 rs1695 gene polymorphism is associated with granulocytopenia induced by platinum-based drugs. 30238837 2018
Acute pancreatitis
CUI: C0001339
Disease: Acute pancreatitis
0.010 GeneticVariation BEFREE The presence of GSTM1 is associated with increased susceptibility for AP, and the GSTP1 Val105Ile SNP is associated with an increased risk for AP in men. 27984487 2017
Obesity
CUI: C0028754
Disease: Obesity
0.010 GeneticVariation BEFREE Impact of the Ile105Val Polymorphism of the Glutathione S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic Risk in Young Adult Population. 28561194 2017
Occupational Diseases
CUI: C0028797
Disease: Occupational Diseases
0.010 GeneticVariation BEFREE Ile105Val (rs1695) in glutathione S-transferase P1 (GSTP1) gene influences cytological toxicity and modulates the risk to occupational diseases. 28153749 2017
Influenza-like symptoms
CUI: C0392171
Disease: Influenza-like symptoms
0.010 GeneticVariation BEFREE Mutant types of rs1041983 (N-acetyltransferase 2 gene, NAT2) had a synergetic effect with passive smoking on ILI frequency, while mutant types of rs1695 (glutathione S-transferase P1 gene, GSTP1) had an antagonistic effect. 28259080 2017
Influenza-like illness
CUI: C0521839
Disease: Influenza-like illness
0.010 GeneticVariation BEFREE Mutant types of rs1041983 (N-acetyltransferase 2 gene, NAT2) had a synergetic effect with passive smoking on ILI frequency, while mutant types of rs1695 (glutathione S-transferase P1 gene, GSTP1) had an antagonistic effect. 28259080 2017
Carpal Tunnel Syndrome
CUI: C0007286
Disease: Carpal Tunnel Syndrome
0.010 GeneticVariation BEFREE The GSTM1 null genotype may be related with the development of CTS, whereas the Val allele of GSTP1-Ile105Val polymorphism may be associated with worse functional and clinical status in CTS. 25566970 2016
Leukemia, Myelocytic, Acute
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
0.010 GeneticVariation BEFREE The purpose of the study was to evaluate the association between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val gene polymorphisms and acute myeloid leukemia risk, in a case-control study comprising 102 patients and 303 controls. 26823947 2016
Myeloproliferative disease
CUI: C0027022
Disease: Myeloproliferative disease
0.010 GeneticVariation BEFREE Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 C>T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms. 27077777 2016