|
Carcinoma, Ovarian Epithelial
|
|
0.060 |
GeneticVariation
|
BEFREE |
<i>GSTP1</i> rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes.
|
30038720 |
2018 |
|
ovarian neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
<i>GSTP1</i> rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes.
|
30038720 |
2018 |
|
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
<i>GSTP1</i> rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes.
|
30038720 |
2018 |
|
Leukopenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>GSTP1</i> rs1695 showed the smallest p value for hematotoxicity association, and the <sup>105</sup>Ile wild type allele had a significantly higher risk of severe hematotoxicity (neutropenia G4, thrombocytopenia ≥ G3 and anemia ≥ G3) than the <sup>105</sup>Val allele (p=0.00034, odds ratio=5.71 (95% confidence interval:1.77-18.44)).
|
30038720 |
2018 |
|
Neutropenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>GSTP1</i> rs1695 showed the smallest p value for hematotoxicity association, and the <sup>105</sup>Ile wild type allele had a significantly higher risk of severe hematotoxicity (neutropenia G4, thrombocytopenia ≥ G3 and anemia ≥ G3) than the <sup>105</sup>Val allele (p=0.00034, odds ratio=5.71 (95% confidence interval:1.77-18.44)).
|
30038720 |
2018 |
|
Thrombocytopenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
<i>GSTP1</i> rs1695 showed the smallest p value for hematotoxicity association, and the <sup>105</sup>Ile wild type allele had a significantly higher risk of severe hematotoxicity (neutropenia G4, thrombocytopenia ≥ G3 and anemia ≥ G3) than the <sup>105</sup>Val allele (p=0.00034, odds ratio=5.71 (95% confidence interval:1.77-18.44)).
|
30038720 |
2018 |
|
Anemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
<i>GSTP1</i> rs1695 showed the smallest p value for hematotoxicity association, and the <sup>105</sup>Ile wild type allele had a significantly higher risk of severe hematotoxicity (neutropenia G4, thrombocytopenia ≥ G3 and anemia ≥ G3) than the <sup>105</sup>Val allele (p=0.00034, odds ratio=5.71 (95% confidence interval:1.77-18.44)).
|
30038720 |
2018 |
|
Adenocarcinoma of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma.
|
12010858 |
2002 |
|
Occupational Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Ile105Val (rs1695) in glutathione S-transferase P1 (GSTP1) gene influences cytological toxicity and modulates the risk to occupational diseases.
|
28153749 |
2017 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Polymorphisms (SNP's) in GSTM1 (Present/Null); GSTP1 (Ile105Val), p53 (Arg72Pro), TGFbeta1 (Leu10Pro), c-erbB2 (Ile655Val), and GSTT1 (Null/Present) in breast cancer.
|
18058229 |
2008 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Polymorphisms (SNP's) in GSTM1 (Present/Null); GSTP1 (Ile105Val), p53 (Arg72Pro), TGFbeta1 (Leu10Pro), c-erbB2 (Ile655Val), and GSTT1 (Null/Present) in breast cancer.
|
18058229 |
2008 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
A combination between GSTM1 double-null genotype and rs1695 also showed an association with ALL (P=0.042).
|
27299594 |
2016 |
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
A combination between GSTM1 double-null genotype and rs1695 also showed an association with ALL (P=0.042).
|
27299594 |
2016 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
A combination between GSTM1 double-null genotype and rs1695 also showed an association with ALL (P=0.042).
|
27299594 |
2016 |
|
Malignant Head and Neck Neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
A cost-minimization analysis was planned to compare GSTP1 c.313A>G genotyping versus overall fosaprepitant implementation for patients with head and neck cancer under chemoradiation therapy with high-dose cisplatin.
|
30870506 |
2019 |
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A cost-minimization analysis was planned to compare GSTP1 c.313A>G genotyping versus overall fosaprepitant implementation for patients with head and neck cancer under chemoradiation therapy with high-dose cisplatin.
|
30870506 |
2019 |
|
Wheezing
|
|
0.020 |
GeneticVariation
|
BEFREE |
A suggestive interaction with early maternal smoking was also seen for three GSTP1 SNPs (Intron 5, Intron 6 and Ile105Val) with respect to transient wheeze, but not for ADRB2 and wheeze phenotypes.
|
20210814 |
2010 |
|
Squamous cell carcinoma of the head and neck
|
|
0.050 |
GeneticVariation
|
BEFREE |
ADH1B histidine allele (rs1229984), CYP2E1 rs3813867 heterozygous genotype, and GSTT1 deletion conferred protection against HNSCC (OR: 0.318 [0.04-0.75], OR: 0.13 [0.02-0.94], and OR: 0.12 [0.02-0.60], respectively) while GSTP1 (rs1695) Val/Val genotype was related to an increased risk (OR: 4.12 [1.11-15.31]).
|
25639971 |
2015 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and GSTP1 A313G, methylenetetrahydrofolate reductase (MTHFR) C677T, reduced folate carrier 1 (RFC1) G80A, and breast cancer resistant protein (BCRP) C421A--were associated with hepatotoxicity for 24 patients, no significant difference was detected for genotype and allelic frequencies between the patients with and those without severe treatment-related hepatotoxicity.
|
20670164 |
2010 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and GSTP1 A313G, methylenetetrahydrofolate reductase (MTHFR) C677T, reduced folate carrier 1 (RFC1) G80A, and breast cancer resistant protein (BCRP) C421A--were associated with hepatotoxicity for 24 patients, no significant difference was detected for genotype and allelic frequencies between the patients with and those without severe treatment-related hepatotoxicity.
|
20670164 |
2010 |
|
Squamous cell carcinoma of esophagus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Although there was no association between the GSTT1 deletion polymorphism or the GSTP1 Ile105Val polymorphism with OSCC, our results suggest that the presence of the recently described GSTT2B deletion may have a protective effect on the risk of OSCC in the Mixed Ancestry South African population.
|
22216261 |
2011 |
|
Adenoma of large intestine
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future.
|
22161138 |
2012 |
|
Myeloproliferative disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 C>T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms.
|
27077777 |
2016 |
|
Febrile Neutropenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among Japanese women who received epirubicin and cyclophosphamide as perioperative chemotherapy for early breast cancer, those with the A/A genotype of the GSTP1 polymorphism (rs1695) were more likely to have FN.
|
25008867 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
As expected, wild homozygotes for GSTP1 Ile105Val and EPHX1 slow/very slow phenotypes were associated with susceptibility (P=0.031) and severity (P=0.036) of COPD, respectively.
|
21651746 |
2013 |