rs1695, GSTP1

N. diseases: 100
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE Predictive value of GSTP1 Ile105Val polymorphism in clinical outcomes of chemotherapy in gastric and colorectal cancers: a systematic review and meta-analysis. 27154175 2017
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE The GSTP1 A313G mutant variant was associated with a higher PFS (HR = 0.55, P = 0.001) and OS (HR = 0.60, P = 0.002) in the CRC group. 25677447 2015
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE Results from previous studies have been inconsistent and therefore we investigated the association between the GSTP1 ile105val polymorphism and the copy number variants of the GSTM1 and GSTT1 genes and survival in CRC patients treated with adjuvant/palliative chemotherapy. 24842074 2014
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE GSTP1 I105V polymorphism and susceptibility to colorectal cancer in Kashmiri population. 21711092 2012
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE We also found that GSTP1 Ile105Val might modify the association between intake of poultry cooked with high temperature methods and CRC risk (p = 0.0035), a finding that was stronger among rectal cancer cases. 21618522 2012
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE Glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk: a meta-analysis and HuGE review. 19643601 2010
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE Controversy exists about whether GST polymorphisms (GSTM1 null/present genotype, GSTT1 null/present genotype, GSTP1 Ile105Val and GSTA1 *A/*B) represent risk factors for colorectal cancer. 20207535 2010
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE Genetic polymorphisms in GST genes (GSTP1 Ile105Val, copy-number variants of GSTM1 and GSTT1) that lead to diminished enzyme activity have been associated with increased chemotherapeutic treatment benefit in colorectal cancer patients. 20017670 2010
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: a study of the Dutch Colorectal Cancer Group. 18797455 2008
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: relationships with treatment outcome. 18085999 2008
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.100 GeneticVariation BEFREE The GSTP1 Ile(105)Val polymorphism is associated in a dose-dependent fashion with increased survival of patients with advanced colorectal cancer receiving 5-FU/oxaliplatin chemotherapy. 12072547 2002