rs17107315, SPINK1

N. diseases: 40
Disease: Pancreatic carcinoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.040 GeneticVariation BEFREE Patients with the N34S mutation presented with earlier symptom onset and more dilatation of the main pancreatic duct, followed by more frequent surgical and/or endoscopic intervention and pancreatic cancer development than those without SPINK1 mutations. 17238043 2007
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.040 GeneticVariation BEFREE To our knowledge, this is the first reported case of chronic pancreatitis accompanied by pancreatic cancer in a patient with the SPINK1 N34S mutation. 15084977 2004
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.040 GeneticVariation BEFREE The frequencies of the promotor polymorphisms of IL10-627A, IL10-1117A, TNF-238A and TNF-308A in patients with alcoholic chronic pancreatitis, idiopathic pancreatitis, SPINK1-N34S-associated chronic pancreatitis and pancreatic cancer did not differ significantly from the control group. 14560157 2003
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.040 GeneticVariation BEFREE The N34S mutation of SPINK1 appears not to be a distinct genetic risk factor in patients with sporadic pancreatic cancer. 12649567 2003