rs17110563, TPH2

N. diseases: 7
Disease: MAJOR AFFECTIVE DISORDER 1 ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
MAJOR AFFECTIVE DISORDER 1
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
0.010 GeneticVariation BEFREE Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD. 17905754 2008