|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study suggests that the FADS1 rs174546 SNP and the FADS2 rs174601 SNP are associated with the risk of CAD and IS, and are likely to influence serum lipid levels.
|
26261632 |
2015 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
For the 11% of the population homozygous for the minor T-allele of rs174546 that associates with lower ∆5 FADS activity, high ALA intake and ALA-to-LA intake ratio may be preferable in the prevention of CVD and ischemic stroke.
|
25008580 |
2014 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The association between rs174546 (T<C) and BP z-score as well as the mediating effects of selected key PUFA levels (dihomo-gamma-linolenic acid, DGLA; arachidonic acid, ARA; eicosapentaenoic acid, EPA) or estimated D5D activity (D5D index) and BMI z-score were investigated through path model analyses, adjusting for sex, age, educational level of parents, family history of hypertension, lifestyle factors and blood levels of saturated and monounsaturated fatty acids, triglycerides and low density lipoprotein cholesterol.
|
28732058 |
2017 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Fatty acid desaturase 1 rs174546 (C>T) did not associate with hypertension.
|
29989339 |
2018 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we observed a significant inverse association between dietary DHA and the risk of gastric cancer but found that FADS1 rs174546 and FADS2 rs174583 did not modify the association between dietary n-3 or n-6 PUFAs and gastric cancer risk.
|
29491470 |
2018 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the 11% of the population homozygous for the minor T-allele of rs174546 that associates with lower ∆5 FADS activity, high ALA intake and ALA-to-LA intake ratio may be preferable in the prevention of CVD and ischemic stroke.
|
25008580 |
2014 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study suggests that the FADS1 rs174546 SNP and the FADS2 rs174601 SNP are associated with the risk of CAD and IS, and are likely to influence serum lipid levels.
|
26261632 |
2015 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we observed a significant inverse association between dietary DHA and the risk of gastric cancer but found that FADS1 rs174546 and FADS2 rs174583 did not modify the association between dietary n-3 or n-6 PUFAs and gastric cancer risk.
|
29491470 |
2018 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.
|
27286809 |
2016 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|
19060910 |
2009 |
|
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Metabolic Syndrome X
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
|
Serum total cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
|
30926973 |
2019 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.
|
27286809 |
2016 |
|
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
|
30926973 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Triglycerides measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |