Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Primary angle-closure glaucoma
CUI: C0017606
Disease: Primary angle-closure glaucoma
0.050 GeneticVariation BEFREE Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls. 31713905 2020
Primary angle-closure glaucoma
CUI: C0017606
Disease: Primary angle-closure glaucoma
0.050 GeneticVariation BEFREE Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07). 27272641 2016
Primary angle-closure glaucoma
CUI: C0017606
Disease: Primary angle-closure glaucoma
0.050 GeneticVariation BEFREE Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan. 23441116 2013
Primary angle-closure glaucoma
CUI: C0017606
Disease: Primary angle-closure glaucoma
0.050 GeneticVariation BEFREE This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease. 21655354 2011
Primary angle-closure glaucoma
CUI: C0017606
Disease: Primary angle-closure glaucoma
0.050 GeneticVariation BEFREE In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population. 19633731 2009