|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
And some studies have reported that the G allele of rs17576 might be associated with CAD.
|
23819814 |
2013 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
We explored the association of MMP2 (C-735T, rs2285053), MMP7 (A-181G, rs11568818) and MMP9 (R279Q, rs17576), (P574R, rs2250889), (R668Q, rs17577) genetic variants with LVD in coronary artery disease (CAD) patients.
|
22664146 |
2012 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence that genetic polymorphism of MMP1-1607 1G/2G, MMP3-Gly45lys, MMP3-376 G/C, MMP3-1171 5A/6A, MMP9-1562 C/T and MMP9-R279Q have a small to medium effect on incidence of coronary disease.
|
22226810 |
2012 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The promoter -1562C/T and exon 6 R279Q A/G polymorphisms were determined in 1001 patients with angiographically verified stable CAD and in 204 healthy controls.
|
21963461 |
2012 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
These findings suggest that MMP-9 R279Q, P574R and R668Q may have combined effect in the occurrence of CAD and -1562 CT/TT genotypes may contribute to CAD in diabetics and MI in CAD patients.
|
19283512 |
2010 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls.
|
31713905 |
2020 |
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls.
|
31713905 |
2020 |
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan.
|
23441116 |
2013 |
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan.
|
23441116 |
2013 |
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population.
|
19633731 |
2009 |
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population.
|
19633731 |
2009 |
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Published data on the association between <i>MMP-9</i> polymorphisms (-1562 C > T, rs3918242; Gln279Arg, rs17576 Arg668Gln, rs17577) and asthma susceptibility are inconclusive.
|
30931075 |
2019 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16).
|
23328249 |
2013 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence that genetic polymorphism of MMP1-1607 1G/2G, MMP3-Gly45lys, MMP3-376 G/C, MMP3-1171 5A/6A, MMP9-1562 C/T and MMP9-R279Q have a small to medium effect on incidence of coronary disease.
|
22226810 |
2012 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
MMP-9 -1562C>T and 836G>A (Arg279Gln) were not associated with asthma (p> or =0.15) or asthma severity (p> or =0.13), and TIMP-1 434T>C (Phe124Phe) was not associated with asthma in women (p = 0.094) or men (p = 0.207).
|
16061701 |
2005 |
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We were interested in whether the polymorphisms -T1702A, -C1562T, R279Q and +C6T within the matrix metalloproteinase 9 (MMP-9) gene were associated with asthma in a population of 231 asthmatic children.However, we found no association.
|
16026590 |
2005 |
|
Keratoconus
|
|
0.020 |
GeneticVariation
|
BEFREE |
<b>Conclusions</b>: This study supports the hypothesis of a functional role for <i>COL4A3</i> (rs55703767, G/T), <i>MMP-9</i> (rs17576, A/G) and <i>TIMP-1</i> (rs6609533, A/G) SNPs in the pathogenesis of keratoconus.
|
31397194 |
2020 |
|
Intervertebral Disc Degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, the G allele of rs17576 was found to correlate with more severe grades of disc degeneration.
|
30289281 |
2018 |
|
Prolapsed lumbar disc
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicated that the A allele of rs17576 reduced the risk of LDH by ∼23% on average.
|
30289281 |
2018 |