Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
Germline mutations in CHEK2 (1100delC, IVS2+1G>A and I157T) have been impaired serine/threonine kinase activity and associated with a range of cancer types.
|
22521562 |
2012 |
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
CHEK2 I157T associates with an increased risk of CRC: the association was observed both among familial and sporadic CRC patients.
|
16816021 |
2006 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
In men with a CHEK2 missense mutation I157T, the cancer detection rate among men with an elevated PSA or an abnormal DRE was much higher (10.2%, P=0.0008).
|
23722471 |
2013 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
We genotyped 630 unselected MM patients and over 3700 controls (newborns, age- and sex-matched healthy adults with negative cancer family histories, and the adults selected at random by family doctors) for the prevalence of three common variants of the BRCA2 (T1915M, N991D and N372H) and four common variants of the CHEK2 (1100delC, VS2+1G --> A, I157T and del5395).
|
18024013 |
2008 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Germline mutations in CHK2 (1100delC, IVS2+1G>A and I157T) have been associated with a range of cancer types.
|
23107771 |
2013 |
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
We conclude that the I157T variant of CHEK2 increases the risk of colorectal cancer among MMR-negative, HNPCC/HNPCC-related families in Poland.
|
19876921 |
2010 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
In men with a CHEK2 missense mutation I157T, the cancer detection rate among men with an elevated PSA or an abnormal DRE was much higher (10.2%, P=0.0008).
|
23722471 |
2013 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
The polymorphic variant Ile157Thr in exon 3 of the gene has been demonstrated to enhance the risk of several types of cancer and at the same time to reduce the risk for developing other cancer types.
|
18834326 |
2009 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Germline mutations in CHEK2 (1100delC, IVS2+1G>A and I157T) have been impaired serine/threonine kinase activity and associated with a range of cancer types.
|
22521562 |
2012 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
The frequency, penetrance and epidemiological as well as clinical significance of the two most studied breast cancer-predisposing variants of the CHEK2 gene, 1100delC and I157T, are highlighted in more depth, and additional CHEK2 mutations and their cancer relevance are discussed as well.
|
16998506 |
2006 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
The polymorphic variant Ile157Thr in exon 3 of the gene has been demonstrated to enhance the risk of several types of cancer and at the same time to reduce the risk for developing other cancer types.
|
18834326 |
2009 |
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Rare variants in CHEK2 (I157T and possibly del1100C) also appear to be associated with CRC risk.
|
22294770 |
2012 |
Malignant Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
In total, 26,336 cases and 44,219 controls from 18 case-control studies were used in this meta-analysis, and significant associations of the CHEK2 I157T variant with cancer susceptibility were found (OR, 1.39; 95% CI, 1.19-1.63; p<0.0001), breast cancer (OR=1.58, 95% CI=1.42-1.75, p<0.00001) and colorectal cancer (OR=1.67, 95% CI=1.24-2.26, p=0.0008).
|
23713947 |
2013 |
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.
|
22901170 |
2012 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
Furthermore, the higher frequency of I157T among patients with multiple primary tumours as well as those with a family history of any cancer supports a role for CHEK2 I157T as a susceptibility allele for multiple cancer types.
|
16816021 |
2006 |
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our result demonstrate for the first time that CHEK2 1100delC, IVS2+1G>A and I157T mutations have not been agenetic susceptibility factor for CRC in the Turkish population.
|
22521562 |
2012 |
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
In total, 26,336 cases and 44,219 controls from 18 case-control studies were used in this meta-analysis, and significant associations of the CHEK2 I157T variant with cancer susceptibility were found (OR, 1.39; 95% CI, 1.19-1.63; p<0.0001), breast cancer (OR=1.58, 95% CI=1.42-1.75, p<0.00001) and colorectal cancer (OR=1.67, 95% CI=1.24-2.26, p=0.0008).
|
23713947 |
2013 |
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
We conclude that the I157T mutation increases the risk of colorectal cancer in the population, but that truncating mutations may confer a lower risk or no increase in risk.
|
17106448 |
2007 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
Germline mutations in CHK2 (1100delC, IVS2+1G>A and I157T) have been associated with a range of cancer types.
|
23107771 |
2013 |
Primary malignant neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
We genotyped 630 unselected MM patients and over 3700 controls (newborns, age- and sex-matched healthy adults with negative cancer family histories, and the adults selected at random by family doctors) for the prevalence of three common variants of the BRCA2 (T1915M, N991D and N372H) and four common variants of the CHEK2 (1100delC, VS2+1G --> A, I157T and del5395).
|
18024013 |
2008 |
Malignant neoplasm of colon and/or rectum
|
|
0.070 |
GeneticVariation
|
BEFREE |
CHEK2 I157T associates with familial and sporadic colorectal cancer.
|
16816021 |
2006 |
Malignant neoplasm of colon and/or rectum
|
|
0.070 |
GeneticVariation
|
BEFREE |
The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.
|
22901170 |
2012 |
Malignant neoplasm of colon and/or rectum
|
|
0.070 |
GeneticVariation
|
BEFREE |
In total, 26,336 cases and 44,219 controls from 18 case-control studies were used in this meta-analysis, and significant associations of the CHEK2 I157T variant with cancer susceptibility were found (OR, 1.39; 95% CI, 1.19-1.63; p<0.0001), breast cancer (OR=1.58, 95% CI=1.42-1.75, p<0.00001) and colorectal cancer (OR=1.67, 95% CI=1.24-2.26, p=0.0008).
|
23713947 |
2013 |
Malignant neoplasm of colon and/or rectum
|
|
0.070 |
GeneticVariation
|
BEFREE |
CHEK2 I157T and colorectal cancer in Bulgaria.
|
20658728 |
2010 |
Malignant neoplasm of colon and/or rectum
|
|
0.070 |
GeneticVariation
|
BEFREE |
We conclude that the I157T variant of CHEK2 increases the risk of colorectal cancer among MMR-negative, HNPCC/HNPCC-related families in Poland.
|
19876921 |
2010 |