Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of colon and/or rectum
0.070 GeneticVariation BEFREE In total, 26,336 cases and 44,219 controls from 18 case-control studies were used in this meta-analysis, and significant associations of the CHEK2 I157T variant with cancer susceptibility were found (OR, 1.39; 95% CI, 1.19-1.63; p<0.0001), breast cancer (OR=1.58, 95% CI=1.42-1.75, p<0.00001) and colorectal cancer (OR=1.67, 95% CI=1.24-2.26, p=0.0008). 23713947 2013
Malignant neoplasm of colon and/or rectum
0.070 GeneticVariation BEFREE The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis. 22901170 2012
Malignant neoplasm of colon and/or rectum
0.070 GeneticVariation BEFREE CHEK2 I157T and colorectal cancer in Bulgaria. 20658728 2010
Malignant neoplasm of colon and/or rectum
0.070 GeneticVariation BEFREE We conclude that the I157T variant of CHEK2 increases the risk of colorectal cancer among MMR-negative, HNPCC/HNPCC-related families in Poland. 19876921 2010
Malignant neoplasm of colon and/or rectum
0.070 GeneticVariation BEFREE The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. 18996005 2009
Malignant neoplasm of colon and/or rectum
0.070 GeneticVariation BEFREE We conclude that the I157T mutation increases the risk of colorectal cancer in the population, but that truncating mutations may confer a lower risk or no increase in risk. 17106448 2007
Malignant neoplasm of colon and/or rectum
0.070 GeneticVariation BEFREE CHEK2 I157T associates with familial and sporadic colorectal cancer. 16816021 2006