Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of the head and neck
0.060 GeneticVariation BEFREE We evaluated the correlation of the x-ray repair cross complementing gene 1 (XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients treated with concurrent chemoradiation therapy (CCRT). 29893275 2018
Squamous cell carcinoma of the head and neck
0.060 GeneticVariation BEFREE These results indicate that both Arg194Trp and Arg399Gln polymorphisms were not associated with the development of HNSCC in Turkish population. 26011347 2015
Squamous cell carcinoma of the head and neck
0.060 GeneticVariation BEFREE In XRCC1 polymorphisms, Arg194Trp and Arg399Gln variants showed a reduced risk, whereas, XPD Lys751Gln variants exhibited ∼2-fold increase in SCCHN risk. 21945240 2012
Squamous cell carcinoma of the head and neck
0.060 GeneticVariation BEFREE Finally, we identified the combined Arg194Trp-Arg399Arg genotype of base excision repair gene XRCC1 that was associated with HNSCC and may have an impact on identification of a high-risk cancer population. 19284666 2009
Squamous cell carcinoma of the head and neck
0.060 GeneticVariation BEFREE In addition, the interaction of CYP2E1 (CYP2E1*5B and CYP2E1*6) with other genetic factors (null genotype of glutathione-S-Transferase M1, GSTM1, X-Ray Repair Cross Complementing Group I, XRCC1 (Arg194Trp), and environmental risk factors such as alcohol and tobacco in modifying HNSCC risk were investigated. 19334053 2009
Squamous cell carcinoma of the head and neck
0.060 GeneticVariation BEFREE In conclusion, the result from our study provides additional evidence of an association of the XRCC1 polymorphism (Arg194Trp) with SCCHN as markers of genetic susceptibility in the Korean population. 15252855 2004