rs1799883, FABP2

N. diseases: 36
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied. 27778448 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2). 28738793 2017
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE We identified 5 studies for Ala54Thr association with obesity in Asian subjects. 26238699 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE However, no significant association was found between T2DM and the FABP2 Ala54Thr polymorphism. 25730055 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The FABP2 Ala54Thr polymorphism was significantly associated with obesity (AT vs AA: OR = 2.633, 95%CI = 1.065-6.663, P = 0.036; TT vs AA: OR = 4.160, 95%CI = 1.609-10.757, P = 0.003) and metabolic syndrome (TT vs AA: OR = 2.273, 95%CI = 1.242-4.156, P = 0.008) by logistic regression with adjustment for covariates. 25730055 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We conclude that the Ala54Thr polymorphism of FABP2 modulates HDL cholesterol in Mexican-Americans with T2D and that Thr54 allele carriers may be responsive in interventions that include dietary changes. 26703680 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The frequencies of FABP2 Ala54Ala, Ala54Thr and Thr54Thr in T2DM cases were 18.39%, 66.66%, 14.94% and 22.72%, 61.36%, 15.90% in controls, respectively. 23468166 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Association between FABP2 Ala54Thr polymorphisms and type 2 diabetes mellitus risk: a HuGE Review and Meta-Analysis. 25388378 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE A54T polymorphism in the fatty acid binding protein 2 studies in a Saudi population with type 2 diabetes mellitus. 24690233 2014
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE To analyze the effect of the fatty acid-binding protein (FABP2) gene Ala54Thr polymorphism on anthropometric and biochemical variables in response to a moderate-fat diet in overweight or obese subjects. 22817827 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The Ala54Thr FABP2 polymorphism was significantly associated with T2DM in HA individuals only (OR: 1.85, 95% CI: 1.05-3.27, p=0.032). 21288588 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The TT genotype in Ala54Thr polymorphism of FABP2 gene in patients with type 2 diabetes increased dietary FA absorption, and this might increase the susceptibility to the effects of dietary lipids. 20484485 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on insulin resistance and adipocytokines in patients with diabetes mellitus type 2. 20329566 2010
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE FABP2 A54T polymorphism may help identify Caucasian subjects at risk for obesity. 19324445 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE 242 subjects with T2DM and 188 control subjects were genotyped for the FABP2 A54T polymorphism using PCR-RFLP method. 19324445 2009
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Influence of ALA54THR polymorphism of fatty acid-binding protein 2 on obesity and cardiovascular risk factors. 17992640 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Studies on the association of fatty acid-binding protein 2 (FABP2) A54T and promoter polymorphism, and type 2 diabetes mellitus, insulin, and triglyceride levels are controversial. 17512303 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We conclude that the T54 allele of FABP2 A54T is associated both with higher BMI and reduced risk of T2DM in women from the German EPIC-Potsdam study. 16718632 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The Ala54Thr polymorphism was not associated with type 2 diabetes mellitus or obesity. 16919542 2006
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The Ala54Thr polymorphism was not associated with type 2 diabetes mellitus or obesity. 16919542 2006
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The aim of this study was to assess the frequency of fatty acid binding protein 2 (FABP2) Ala54Thr genetic polymorphism and to evaluate its association with obesity and insulin resistance in Chilean aboriginal populations. 17211557 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Similarly, Ala/Ala homozygote males carrying the promoter haplotype B had decreased risk (0.33, 0.11 - 0.94, p < 0.05) of type 2 diabetes after stratification for the Ala54Thr polymorphism. 16718625 2006
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Preliminary evidence of FABP2 A54T polymorphism associated with reduced risk of type 2 diabetes and obesity in women from a German cohort. 16718632 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes. 16249461 2005
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Our results suggest that the Ala54Thr polymorphism of the FABP2 gene is associated with obesity and insulin resistance. 14981227 2004