Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.840 GeneticVariation BEFREE Compared with WT/WT, H63D</span>/WT and H63D</span>/H6</span>3D participants had a 2% to 4% and 4% to 7% absolute increase in hypertension risk at each visit, respectively. 30571559 2019
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.840 GeneticVariation BEFREE According to GWAS studies, iron regulatory protein HFE gene variant H63D (rs1799945) was associated with hypertension, an observation which we were able to confirm also in our TAMRISK cohort. 28151915 2017
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.840 GeneticVariation BEFREE We found that individuals with the mutated form of the H63D polymorphic site (G-allele) had a 1.4-fold risk (P = 0.037, 95% confidence interval [CI] 1.02-1.89) for hypertension at the age of 50 years compared with the CC genotype carriers. 25634189 2015
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.840 GeneticVariation BEFREE Multivariate analysis revealed that the odds of CHF was higher in females [Odds Ratio (OR) = 2·9, P < 0·01], individuals with pre-HCT chest radiation (OR = 4·7, P = 0·05), hypertension (OR = 2·9, P = 0·01), and with variants of genes coding for the NAD(P)H-oxidase subunit RAC2 (rs13058338, 7508T→A; OR = 2·8, P < 0·01), HFE (rs1799945, 63C→G; OR = 2·5, P = 0·05) or the doxorubicin efflux transporter ABCC2 (rs8187710, 1515G→A; OR = 4·3, P < 0·01). 23927520 2013
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.840 GeneticVariation GWASDB Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 21909115 2011
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.840 GeneticVariation GWASCAT Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 21909115 2011