rs1799971, OPRM1

N. diseases: 95
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The single-nucleotide polymorphism, A118G of the mu opioid receptor gene (oprm1), has been associated with altered pain perception. 30873885 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Accordingly, a functional μ-opioid receptor (OPRM1) polymorphism (C77G in primates, A118G in humans) affecting opioidergic signaling has been associated with separation distress and attachment behavior in nonhuman primates, and social pain sensitivity in humans. 31772303 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The Relevance of the OPRM1 118A>G Genetic Variant for Opioid Requirement in Pain Treatment: A Meta-Analysis. 31337162 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Few associations replicated: morphine dose (mcg/kg) in African American children and ABCB1 rs1045642 (A allele, β = -9.30, 95% CI: -17.25 to -1.35, p = 0.02) and OPRM1 rs1799971 (G allele, β = 23.19, 95% CI: 3.27-43.11, p = 0.02); KCNJ6 rs2211843 and high pain in African American subjects (T allele, OR 2.08, 95% CI: 1.17-3.71, p = 0.01) and in congruent European Caucasian pain phenotypes; and COMT rs740603 for high pain in European Caucasian subjects (A allele, OR: 0.69, 95% CI: 0.48-0.99, p = 0.046). 30760877 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol. 31806881 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE In subgroup analysis, we did not find statistically significant correlation between OPRM1 A118G polymorphism and opioid pain relief among Caucasian patients (SMD=-0.15; 95% CI, -0.29 to -0.00; P=0.04), as well as among morphine users (SMD =-0.20; 95% CI, -0.40 to 0.00, P=0.05), except for Asian patients (SMD=-0.42; 95% CI, -0.62 to -0.23; P<0.001). 30028366 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE In comparison, two pain-related gene SNPs (OPRM1 [rs1799971] and COMT [rs4818]) interacted with psychological factors to predict four shoulder impairment phenotypes (abduction: 5-day average loss; strength loss: 5-day average, peak, and relative loss). 30425562 2018
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The single nucleotide polymorphism of the μ-opioid receptor, OPRM1 A118G, has been associated with greater drug and alcohol use, increased sensitivity to pain, and reduced sensitivity to the antinociceptive effects of opiates. 28939474 2018
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE In addition, given the prominent role of the opioid system in pain signaling, we investigated the effects of acute alcohol exposure on PIP5K1C expression in humanized transgenic mice for the μ-opioid receptor that included the OPRM1 A118G polymorphism, a widely used mouse model to study analgesic response to opioids in pain. 29667742 2018
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE This OPRM1 A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience. 28057931 2017
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE For patients with no copies of the LPS haplotype, AA of OPRM1 A118G was significantly associated with higher pain scores compared to the variant AG/GG. 27903758 2017
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Thus, the data demonstrated that the rare allele of MMP9 rs17576 was associated with poor pain recovery, whereas the rare allele of OPRM1 rs1799971 was associated with better pain recovery at 5-year follow-up in the LBP and LRP patients. 28471875 2017
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE OPRM1 rs1799971 and the combined OPRM1/COMT genotype could serve as biomarkers for pain sensitivity. 27541715 2016
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transporter, C3435T), COMT gene (pain sensitivity, G1947A), and UGT2B7 gene (opioid metabolism, -G840A) were tested. 25576257 2015
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The results indicate that among the genetic SNPs we studied which include those affecting analgesic drug metabolism, transport of analgesic agents across the blood-brain barrier, and their activity at target receptors and ion channels and in the modulation of neurotransmitter pathways, the A118G allele variant of OPRM1 has the most potent influence on pain management of postoperative patients. 25794200 2015
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Our results demonstrate that the A118G OPRM1 polymorphism contributes to interindividual variations in the function of neurotransmitters responsive to pain (endogenous opioid and dopamine), as well as their regulation through cognitive-emotional influences in the context of therapeutic expectations, the so-called placebo effect. 25308352 2015
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Several studies have shown that human carriers of the single nucleotide polymorphism of the μ-opioid receptor, OPRM1 A118G, exhibit greater drug and alcohol use, increased sensitivity to pain, and reduced sensitivity to the antinociceptive effects of opiates. 25449401 2015
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE In line with suggestions of a common neural network involved in the processing of physical pain and negative and distressing stimuli, like social rejection as a psychologically harmful event, we examined the influence of the A118G polymorphism on the neural processing of physical and non-physical pain. 26019010 2015
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Genetic variants in OPRM1, particularly the non-synonymous polymorphism A118G, have been repeatedly associated with the efficacy of treatments for pain and various types of dependence. 24201053 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE No association was found between 118A>G and experimental pain 25239082 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE In a subpopulation, identifying OPRM1 A118G polymorphism may provide valuable information regarding the individual analgesic doses that are required to achieve satisfactory pain control. 25102313 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The present data indicate that, when controlling for pain intensity and duration, subjective health complaints are associated with a sex - OPRM1 A118G polymorphism interaction in patients with radicular pain. 24884878 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE No difference was observed between fibromyalgia patients with and without the A118G allele with regard to the Beck Depression Inventory, widespread pain index, symptom severity, and Fibromyalgia Impact Questionnaire scores. 24671502 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE µ-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain. 24236490 2013
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain. 23803057 2013