|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, a mutation, Glu298Asp, in exon 7 of NOS3 and a 27 bp variable number tandem repeat (VNTR) marker in intron 4 of NOS3 were evaluated in the sibling pairs and in an additional 92 unrelated African-Americans with type 2 diabetes mellitus-associated ESRD (singletons).
|
11071967 |
2000 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males.
|
11823442 |
2002 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
These data indicated that Glu298Asp is the predisposing factor in ESRD, especially DM-derived ESRD.
|
12364359 |
2002 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The endothelial nitric oxide synthase Glu298Asp and Asp29Asp genotypes were significantly more frequent in rapid progressors (9.6% (7/73) Asp/Asp, 39.7% (29/73) Asp/Glu, 50.7% (37/73) Glu/Glu) and in ADPKD group with ESRF between 40-63 years (11.3% (16/142) Asp/Asp, 41.5% (59/142) Asp/Glu, 47.2% (67/142) Glu/Glu) in comparison with slow progressors (8.8% (8/91) Asp/Asp, 24.2% (22/91) Asp/Glu, 67.0% (61/91) Glu/Glu) and with control group (8% Asp/Asp, 32% Asp/Glu, 60% Glu/Glu) (Chi-square test, p<0.05).
|
15287194 |
2004 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease.
|
16148605 |
2005 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
|
16364824 |
2005 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested the relationship between carotid intima-media thickness (IMT) and three endothelial NO synthase (eNOS) polymorphisms (G894T, T-786C, and 27-bp repeat in intron 4) in an ethnically and geographically homogeneous group of 147 patients with ESRD.
|
17586410 |
2007 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
It appears that Glu298Asp may be a predisposing factor in DM-derived and HT-derived ESRD.
|
18793530 |
2008 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggested that the Glu298Asp polymorphism of NOS3 gene is associated with the onset age of ESRD.
|
18815450 |
2008 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Impact of nitric oxide synthase Glu298Asp polymorphism on the development of end-stage renal disease in type 2 diabetic Egyptian patients.
|
21854353 |
2011 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Since the Glu298Asp variant in the eNOS gene alters caveolar localization of the corresponding enzyme, we tested the interaction between this variant and the rs4730751 polymorphism of the caveolin-1 (CAV-1) gene as related to arterial remodeling in end-stage renal disease (ESRD) patients.
|
21976276 |
2012 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a link between eNOS Glu298Asp gene polymorphism and ESRD risk was not found in Caucasians and Brazil population.
|
23464568 |
2013 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The evidence accumulated suggested that 4b/a and G894T polymorphisms in the eNOS gene were associated with ESRD susceptibility, indicating that 4a and T allele carriers might become significant genetic molecular markers for the onset of ESRD in overall populations.
|
24673298 |
2014 |
|
Kidney Failure, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
GG genotype of the Glu298Asp variant slowed the ESRD progression in ADPKD, while a allele carriers of the 4b/a variant increased the risk of ESRD.
|
24995932 |
2014 |