|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses yielded similar positive results for G894T SNP in essential hypertension, gestational hypertension, and Asian ethnicity, and that for T-786C SNP in essential hypertension and Asian population.
|
28287883 |
2017 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Impact of obesity and nitric oxide synthase gene G894T polymorphism on essential hypertension.
|
26579574 |
2015 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We explored the associations of the G894T polymorphism with 24-h ambulatory blood pressure, left ventricular mass (LVM), carotid intima media thickness (cIMT), urinary albumin excretion, oxidative stress and inflammatory parameters in 126 children with newly diagnosed PH and in 83 healthy children.
|
26227630 |
2015 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present case-control study failed to show significant association of G894T variant with EH in northern Han Chinese.
|
24846690 |
2015 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population.
|
23613274 |
2013 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we investigated the association of three clinically relevant polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) in a case-control sample of 230 ethnically homogeneous (Caucasians) patients with essential hypertension, with (n = 64) and without (n = 166) clinically diagnosed LVH.Haplotype analysis was also performed.
|
20482221 |
2010 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we investigated the role of the -922A/G, -786T/C, 4b/4a, and 894G/T polymorphisms of the NOS3 and NO(x) levels in 800 consecutive unrelated subjects comprising 455 patients of essential hypertension and 345 controls.
|
18325347 |
2008 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of eNOS Glu298Asp gene polymorphism with essential hypertension in Asian Indians.
|
17935708 |
2008 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study suggested an association between a G894T polymorphism of eNOS gene and EH in Hani and Yi minority groups of China.
|
18164968 |
2008 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gender specific association of endothelial nitric oxide synthase gene (Glu298Asp) polymorphism with essential hypertension in a south Indian population.
|
18582449 |
2008 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.
|
16765468 |
2007 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Up to now, there has been conflicting data regarding the association between three clinically relevant polymorphisms (T-786C, intron4b/a and G894T) of the eNOS gene and essential hypertension.
|
16834924 |
2006 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension.
|
16109907 |
2005 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evidence for the involvement of eNOS single nucleotide polymorphisms in the development of essential hypertension is limited, though the eNOS Glu298Asp polymorphism appears to influence the blood pressure response to exercise.
|
12530931 |
2003 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Indeed, a missense mutation in the endothelial NO gene caused by a Glu298Asp alteration has been strongly associated with essential hypertension, coronary artery spasm, and myocardial infarction.
|
11967250 |
2002 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu298Asp polymorphism may contribute to the complex pathogenesis of essential hypertension and may be a factor in the resistance of these patients to conventional antihypertensive therapy.
|
11394896 |
2001 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Given the evidence of positive association of another polymorphism in the eNOS gene, the Glu298Asp polymorphism, with essential hypertension, special attention will be required to interpret the results of a case-control study for genetic risk factors.
|
11131266 |
2000 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant association between a Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene and essential hypertension was recently reported in Japanese populations, with the 298Asp variant showing a higher prevalence in hypertensive patients (10.3% to 12.0%) than in normotensive subjects (5.0% to 5.8%).
|
10205226 |
1999 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the Glu298Asp missense variant was significantly associated with essential hypertension, which suggests that it is a genetic susceptibility factor for essential hypertension.
|
9674630 |
1998 |