rs1799983, NOS3

N. diseases: 246
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE There was a significant association of the missense Glu298Asp variant of the eNOS gene with MI. 9626827 1998
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE We have identified a missense variant, Glu298Asp, in exon 7 of the eNOS gene and demonstrated that it is associated with both coronary spastic angina and myocardial infarction. 9674630 1998
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Homozygosity for a common NOS 3 polymorphism (894 G-->T) which encodes a Glu298-->Asp amino acid substitution in eNOS is a risk factor for angiographic CAD and recent MI in this population. 10510054 1999
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Recently, a Glu298Asp variant of the endothelial nitric oxide synthase gene (NOS3) was identified as being associated with coronary spasm and myocardial infarction, whereas it has been reported that endothelial nitric oxide synthase plays a role in HP. 11745998 2001
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The present data extends earlier observations by the findings that predominantly younger T allele carriers of the ecNOS Glu(298)Asp gene polymorphism with various coronary high-risk profiles had an increased risk to suffer CAD and/or MI. 11755935 2002
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The aims of this study were to assess whether any association exists between the Glu298Asp variant of the eNOS gene and the risk of CAD and/or MI among Taiwanese. 11802531 2001
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Indeed, a missense mutation in the endothelial NO gene caused by a Glu298Asp alteration has been strongly associated with essential hypertension, coronary artery spasm, and myocardial infarction. 11967250 2002
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE An endothelial nitric oxide synthase gene (NOS3) polymorphism in exon 7 (G894T), resulting in Glu298Asp substitution at protein level, has been associated with myocardial infarction, hypertension and coronary atherosclerosis in some populations. 12113283 2002
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE In addition, a missense Glu298Asp mutation in exon 7 of the eNOS gene is reported to be a risk factor for hypertension or myocardial infarction. 12701818 2003
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The TT genotype of the single nucleotide polymorphism 894 G/T, located in exon 7 of the eNOS gene, was found to be associated with coronary spasm, coronary artery disease (CAD) and myocardial infarction (MI). 12727149 2003
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE G894T polymorphism on the eNOS gene increases the risk for premature MI and modifies the response of vascular endothelium during the acute phase of MI by affecting the release of vWF, IL-6, and oxidative stress status, an effect diminished one year after the event. 16168297 2005
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE This finding implies that genetic polymorphism G894T on eNOS may affect endothelial function in patients with a history of premature myocardial infarction. 16337503 2006
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Consistently, high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms were significantly associated with onset of a first MI at age <50 years (adjusted odds ratio 1.70, p = 0.005, adjusted odds ratio 2.15, p = 0.01, respectively). 17437735 2007
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Cases (all-cause death, nonfatal myocardial infarction (MI), or nonfatal stroke) and an age-, sex-, race/ethnicity-matched control population were genotyped for the -786T>C and Glu298>Asp polymorphisms in NOS3. 19407804 2009
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE This study indicates that E298D polymorphism of the eNOS gene seems to be associated with MI occurrence in the Greek population. 20854685 2010
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE We studied whether the NAMPT rs1319501, AKT1 rs3730358, p53 rs1042522, Mdm2 rs2279744 or eNOS rs1799983 SNP:s linked to NAMPT and Akt signaling associate with risk of myocardial infarction (MI). 22251423 2012
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE A significant difference was observed in the distribution of GT genotype of the NOS3 894G>T polymorphism between the cases and the risk controls (p = 0.05) but the odds ratio (0.6) did not show risk for MI. 23108994 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Genotype and allele distributions of G894T and intron 4a/b polymorphisms were not significantly different between T2DM subjects with and without CAD/MI. 23182401 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Our data suggest that the T786C and the G894T genetic polymorphisms are associated with the development of MI in very young individuals, whose coronary arteries are characterized by very small atheromatic burden. 23594558 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE This study investigated the relationship of the -786T>C (rs2070744), 894G>T (rs1799983) and 4a4b polymorphisms of the NOS3 gene with the presence of MI in the Tunisian population. 24095258 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The results indicate that ethnicity plays important roles in the association between eNOS G894T polymorphism and MI. 24498040 2014
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286). 26662939 2016
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE In conclusion, we confirmed that the eNOS G894T polymorphism is a risk factor for premature CAD, particularly in those suffering premature MI.</span> 29100441 2017
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE When we stratified data based on type of disease, we found that the rs1799983, rs2070744 and rs869109213 polymorphisms were all significantly correlated with the risk of myocardial infarction or acute coronary syndrome in certain genetic models. 30789045 2019