|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
G894T polymorphism on the eNOS gene increases the risk for premature MI and modifies the response of vascular endothelium during the acute phase of MI by affecting the release of vWF, IL-6, and oxidative stress status, an effect diminished one year after the event.
|
16168297 |
2005 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant difference was observed in the distribution of GT genotype of the NOS3 894G>T polymorphism between the cases and the risk controls (p = 0.05) but the odds ratio (0.6) did not show risk for MI.
|
23108994 |
2013 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
An endothelial nitric oxide synthase gene (NOS3) polymorphism in exon 7 (G894T), resulting in Glu298Asp substitution at protein level, has been associated with myocardial infarction, hypertension and coronary atherosclerosis in some populations.
|
12113283 |
2002 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cases (all-cause death, nonfatal myocardial infarction (MI), or nonfatal stroke) and an age-, sex-, race/ethnicity-matched control population were genotyped for the -786T>C and Glu298>Asp polymorphisms in NOS3.
|
19407804 |
2009 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Consistently, high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms were significantly associated with onset of a first MI at age <50 years (adjusted odds ratio 1.70, p = 0.005, adjusted odds ratio 2.15, p = 0.01, respectively).
|
17437735 |
2007 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype and allele distributions of G894T and intron 4a/b polymorphisms were not significantly different between T2DM subjects with and without CAD/MI.
|
23182401 |
2013 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for a common NOS 3 polymorphism (894 G-->T) which encodes a Glu298-->Asp amino acid substitution in eNOS is a risk factor for angiographic CAD and recent MI in this population.
|
10510054 |
1999 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, a missense Glu298Asp mutation in exon 7 of the eNOS gene is reported to be a risk factor for hypertension or myocardial infarction.
|
12701818 |
2003 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, we confirmed that the eNOS G894T polymorphism is a risk factor for premature CAD, particularly in those suffering premature MI.</span>
|
29100441 |
2017 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286).
|
26662939 |
2016 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Indeed, a missense mutation in the endothelial NO gene caused by a Glu298Asp alteration has been strongly associated with essential hypertension, coronary artery spasm, and myocardial infarction.
|
11967250 |
2002 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that the T786C and the G894T genetic polymorphisms are associated with the development of MI in very young individuals, whose coronary arteries are characterized by very small atheromatic burden.
|
23594558 |
2013 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a Glu298Asp variant of the endothelial nitric oxide synthase gene (NOS3) was identified as being associated with coronary spasm and myocardial infarction, whereas it has been reported that endothelial nitric oxide synthase plays a role in HP.
|
11745998 |
2001 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of this study were to assess whether any association exists between the Glu298Asp variant of the eNOS gene and the risk of CAD and/or MI among Taiwanese.
|
11802531 |
2001 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present data extends earlier observations by the findings that predominantly younger T allele carriers of the ecNOS Glu(298)Asp gene polymorphism with various coronary high-risk profiles had an increased risk to suffer CAD and/or MI.
|
11755935 |
2002 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results indicate that ethnicity plays important roles in the association between eNOS G894T polymorphism and MI.
|
24498040 |
2014 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of the single nucleotide polymorphism 894 G/T, located in exon 7 of the eNOS gene, was found to be associated with coronary spasm, coronary artery disease (CAD) and myocardial infarction (MI).
|
12727149 |
2003 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant association of the missense Glu298Asp variant of the eNOS gene with MI.
|
9626827 |
1998 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
This finding implies that genetic polymorphism G894T on eNOS may affect endothelial function in patients with a history of premature myocardial infarction.
|
16337503 |
2006 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study indicates that E298D polymorphism of the eNOS gene seems to be associated with MI occurrence in the Greek population.
|
20854685 |
2010 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study investigated the relationship of the -786T>C (rs2070744), 894G>T (rs1799983) and 4a4b polymorphisms of the NOS3 gene with the presence of MI in the Tunisian population.
|
24095258 |
2013 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have identified a missense variant, Glu298Asp, in exon 7 of the eNOS gene and demonstrated that it is associated with both coronary spastic angina and myocardial infarction.
|
9674630 |
1998 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied whether the NAMPT rs1319501, AKT1 rs3730358, p53 rs1042522, Mdm2 rs2279744 or eNOS rs1799983 SNP:s linked to NAMPT and Akt signaling associate with risk of myocardial infarction (MI).
|
22251423 |
2012 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
When we stratified data based on type of disease, we found that the rs1799983, rs2070744 and rs869109213 polymorphisms were all significantly correlated with the risk of myocardial infarction or acute coronary syndrome in certain genetic models.
|
30789045 |
2019 |