rs1799983, NOS3

N. diseases: 246
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Recently, a common polymorphism in exon 7 of the eNOS gene (894G-->T) has been reported to be a strong risk factor for coronary artery disease. 9731617 1998
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease. 10475066 1999
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE A missense mutation of the nitric oxide synthase (eNOS) gene (Glu298Asp) in five patients with coronary artery disease--case reports. 10451235 1999
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK. 10510054 1999
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Recently two polymorphisms, the 27-bp repeat sequence in intron 4 and the Glu298Asp substitution in exon 7 of the eNOS gene have been reported to be related to coronary heart disease (CHD). 11043380 2000
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE We recently identified two endothelial nitric oxide synthase (eNOS) gene polymorphisms, Glu298Asp and T-786-->C, which are independently associated with coronary spasm. eNOS gene intron 4b/a polymorphism is also reported to be involved in smoking-dependent coronary artery disease. 10979242 2000
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Lack of association between the Glu298Asp variant of the endothelial nitric oxide synthase gene and the risk of coronary artery disease among Taiwanese. 11802531 2001
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease. 11579346 2001
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile. 11755935 2002
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Glu298-->Asp polymorphism of the eNOS gene appears to be associated with the presence, extent, and severity of angiographically assessed coronary artery disease. 12010932 2002
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease. 14989558 2003
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations. 12641536 2003
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population. 15483745 2004
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Endothelial nitric oxide synthase (eNOS), which produces NO, plays an important role in the endothelial function under a wide range of physiological conditions. eNOS exon 7 polymorphism (Glu298Asp, G894T) has been considered to influence the risk of coronary artery disease. 15595935 2005
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. 16616056 2006
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07). 17108813 2006
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE However, there was evidence that small studies with more striking results could affect the associations of the Glu298Asp and -786T>C polymorphisms with coronary heart disease. 17018701 2006
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE We systematically examined the associations of eight variants of the eNOS gene (two potentially functional variants [-786T>C and Glu298Asp] and six tagging single nucleotide polymorphisms) with CHD risk in a large cohort of diabetic patients. 16804086 2006
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE The eNOS -786T>C (odds ratio [OR]; 1.61, 95% confidence interval [CI]; 0.97-2.69), 894G>T (OR; 1.12, 95% CI; 0.65-1.92) and 4a4b (OR; 1.44, 95% CI; 0.87-2.39) polymorphisms were not an independent predisposition factor to coronary artery disease. 16842840 2007
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Our data indicate that the eNOS 894G>T polymorphism is associated with increased CHD risk. 18844489 2008
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial. 20083095 2010
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease. 19434512 2010
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population. 20470943 2010
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease. 22045428 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. 21816783 2011