|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
As for vascular complications in DM, significant associations with the susceptibility to diabetic nephropathy were detected for the rs1799983 and rs2070744 polymorphisms.
|
30140993 |
2018 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study is to quantify global DNA methylation and investigate the relationship with diabetes status and polymorphisms in MTHFR C677T and NOS3 G894T genes in mixed ancestry subjects from South Africa.
|
27990443 |
2016 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes mellitus and late-onset hypogonadism: the role of Glu298Asp endothelial nitric oxide synthase polymorphism.
|
25228279 |
2015 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the NOS3 G894T variant was not independently associated with diabetes in either African Americans or whites, significant interaction between BMI and the NOS3 polymorphism indicated that obesity was an effect modifier of diabetes risk for white individuals with the TT genotype (odds ratio (OR) for interaction = 1.65, p = 0.04).
|
24278136 |
2013 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes.
|
24603156 |
2013 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the frequency of eNOS G894T variant and to find the possible association between this polymorphism with CAD we studied 207 unrelated patients with total CAD (with and without diabetes) and 92 controls.
|
21602253 |
2012 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the present study demonstrates that there is an association of endothelial nitric oxide synthase gene (G894T) polymorphism with diabetes mellitus among South Indians.
|
22110783 |
2011 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Regarding eNOS G894T gene polymorphisms, 47.4% of the patients had GG (n = 46), 47.4% (n = 46) had GT, and 5.2% (n = 5) had TT alleles in the diabetes mellitus group, and 47.0% (n = 48), 41.2% (n = 42), and 11.8% (n = 12) had GG, GT, and TT alleles in the control group, respectively.
|
20642368 |
2010 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis showed that G894T is significantly associated with diabetic nephropathy and diabetes leading to severe nephropathy in type 2 diabetics and in East Asians, respectively.
|
19773668 |
2009 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
With multivariate analysis, our data identified that aging, diabetes mellitus (DM), and eNOS G894T gene polymorphism were three independent common risk factors for both ED and BPH/LUTS (P < 0.001, P = 0.036, and P = 0.039 for ED; P = 0.034, P = 0.004, and P = 0.016 for BPH/LUTS, respectively).
|
19515207 |
2009 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast, the T allele is associated with increased oxidative stress in the renal circulation in patients with diabetes suggesting a specific role of the G894T polymorphism in the pathogenesis of diabetic nephropathy.
|
18622262 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant interaction between diabetes mellitus and eNOS Glu298Asp polymorphism in the analysis of collateral development.
|
18001743 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency of CC (-786T > C), TT (894G > T) and aa genotypes (27VNTR) were significantly higher in diabetic nephropathy patients as compared to the diabetes without nephropathy group (CC: P = 0.003, TT: P = 0.03, aa: P < 0.0001).
|
18401556 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Age at onset of diabetes, male sex, duration of diabetes, HbA1c, blood pressure and smoking were assessed as possible confounders in the logistic regression analysis, which showed that homozygosity for the Glu-allele of the Glu298Asp-polymorphism was independently associated with increased risk of DN (OR = 1.46; 95% CI = 1.12-1.91).
|
17101543 |
2006 |