|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians.
|
30789045 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings show that the 27-bp VNTR polymorphic locus, but not the c.894G>T polymorphic locus, is associated with CAD and that it may regulate NOS3 pre-mRNA splicing in a length-dependent manner.
|
30447355 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between the <i>NOS3</i> rs1799983 polymorphism and CAD may be partly mediated by abnormal NO and lipid levels caused by the T allele.
|
31138610 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we also found that the rs1799983 polymorphism was significantly associated with the susceptibility to peripheral artery disease, whereas the rs2070744 polymorphism was significantly associated with the susceptibility to coronary artery disease in DM patients.
|
30140993 |
2018 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the odds ratio for CAD related to the G894T (OR=1.09, 95% CI=(0.60-2.00), T-786C (OR=1.04, 95% CI=(0.57-1.89) and 4a/4b (OR=1.75, 95% CI=(0.92-3.32) variants did not show statistical significance.
|
30788304 |
2018 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, we confirmed that the eNOS G894T polymorphism is a risk factor for premature CAD, particularly in those suffering premature MI.
|
29100441 |
2017 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, although Glu298Asp did not show association with CAD and lipid profile in the studied cohort, it may exert its effect through blood pressure; however, the mechanism of this effect needs to be explored in the future.
|
28620990 |
2017 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine if the NOS3 genetic variants are associated with CAD in the Han Chinese, we examined the potential association between C</span>AD and eight single nucleotide polymorphisms (rs1799983, rs2070744, rs11771443, rs3918188, rs2853796, rs7830, rs1541861, and rs2853792) of the NOS3 using the MassARRAY system.
|
27323132 |
2016 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients.
|
27613099 |
2016 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the basis of present results, it can be concluded that rs1799</span>983 is strongly associated with coronary artery disease in our population and TT genotype of this polymorphism enhanced the risk of coronary artery disease in Pakistani population.
|
25057159 |
2015 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T>C, 4a4b, and 894G>T) have been previously associated with increased CAD risk.
|
26662450 |
2015 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the G894T (rs1799983) polymorphism of the eNOS gene was associated with CAD in Tunisian patients.
|
25748584 |
2015 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004).
|
26256966 |
2015 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease.
|
24827774 |
2014 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298Asp, T786-C and 27 bp VNTR b/a) with CAD.
|
25409023 |
2014 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta‑analysis of 39 case‑control studies.
|
23443250 |
2013 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype and allele distributions of G894T and intron 4a/b polymorphisms were not significantly different between T2DM subjects with and without CAD/MI.
|
23182401 |
2013 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of present study revealed that eNOS G894T polymorphism is associated with increased risk of CAD in our population.
|
21602253 |
2012 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.
|
22417945 |
2012 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study was conducted to investigate the possible outcome of interaction between endothelial nitric oxide (NOS3) G894T and cholesteryl ester transfer TaqIB variants on the risk of coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM).
|
23157875 |
2012 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotype frequencies for Glu298/Asp (Glu/Glu and Glu/Asp) genotypes were 75% and 25% in CAD subjects and 88% and 12% in control subjects, respectively.
|
22045428 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for Glu298Asp and M235T polymorphisms may predispose to CAD.
|
20547537 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The synthesis of available evidence supports the fact that eNOS G894T andT-786C are associated with CAD.
|
20861627 |
2010 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population.
|
20470943 |
2010 |