Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE The evidence accumulated suggested that 4b/a and G894T polymorphisms in the eNOS gene were associated with ESRD susceptibility, indicating that 4a and T allele carriers might become significant genetic molecular markers for the onset of ESRD in overall populations. 24673298 2014
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE GG genotype of the Glu298Asp variant slowed the ESRD progression in ADPKD, while a allele carriers of the 4b/a variant increased the risk of ESRD. 24995932 2014
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE However, a link between eNOS Glu298Asp gene polymorphism and ESRD risk was not found in Caucasians and Brazil population. 23464568 2013
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE Since the Glu298Asp variant in the eNOS gene alters caveolar localization of the corresponding enzyme, we tested the interaction between this variant and the rs4730751 polymorphism of the caveolin-1 (CAV-1) gene as related to arterial remodeling in end-stage renal disease (ESRD) patients. 21976276 2012
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE Impact of nitric oxide synthase Glu298Asp polymorphism on the development of end-stage renal disease in type 2 diabetic Egyptian patients. 21854353 2011
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE The results suggested that the Glu298Asp polymorphism of NOS3 gene is associated with the onset age of ESRD. 18815450 2008
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE It appears that Glu298Asp may be a predisposing factor in DM-derived and HT-derived ESRD. 18793530 2008
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE We tested the relationship between carotid intima-media thickness (IMT) and three endothelial NO synthase (eNOS) polymorphisms (G894T, T-786C, and 27-bp repeat in intron 4) in an ethnically and geographically homogeneous group of 147 patients with ESRD. 17586410 2007
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease. 16364824 2005
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease. 16148605 2005
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE The endothelial nitric oxide synthase Glu298Asp and Asp29Asp genotypes were significantly more frequent in rapid progressors (9.6% (7/73) Asp/Asp, 39.7% (29/73) Asp/Glu, 50.7% (37/73) Glu/Glu) and in ADPKD group with ESRF between 40-63 years (11.3% (16/142) Asp/Asp, 41.5% (59/142) Asp/Glu, 47.2% (67/142) Glu/Glu) in comparison with slow progressors (8.8% (8/91) Asp/Asp, 24.2% (22/91) Asp/Glu, 67.0% (61/91) Glu/Glu) and with control group (8% Asp/Asp, 32% Asp/Glu, 60% Glu/Glu) (Chi-square test, p<0.05). 15287194 2004
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE These data indicated that Glu298Asp is the predisposing factor in ESRD, especially DM-derived ESRD. 12364359 2002
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males. 11823442 2002
Chronic kidney disease stage 5
CUI: C2316810
Disease: Chronic kidney disease stage 5
0.100 GeneticVariation BEFREE In addition, a mutation, Glu298Asp, in exon 7 of NOS3 and a 27 bp variable number tandem repeat (VNTR) marker in intron 4 of NOS3 were evaluated in the sibling pairs and in an additional 92 unrelated African-Americans with type 2 diabetes mellitus-associated ESRD (singletons). 11071967 2000