rs1800206, PPARA

N. diseases: 35
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.040 GeneticVariation BEFREE We genotyped the Leu162Val polymorphism in 1383 patients with type 2 diabetes and 4401 control subjects with normal glucose tolerance (NGT) without showing any association between diabetes and genotype. 17129741 2007
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.040 GeneticVariation BEFREE In the placebo group, the G (162V) allele of rs1800206 increased the risk for diabetes by 1.9-fold (95% CI 1.05-3.58) and was associated with elevated levels of plasma glucose and insulin. 17317762 2007
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.040 GeneticVariation BEFREE The effect of the L162V polymorphism at the PPARA locus on CV risk depends on the presence of DM/IR. 16221474 2006
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.040 GeneticVariation BEFREE Overall, the PPARalpha haplotype signficantly influenced age at diagnosis (P = 0.027), with the C-L-C and C-V-C haplotypes (intron 1-L162V-intron 7) accelerating onset of diabetes by 5.9 (P = 0.02) and 10 (P = 0.03) years, respectively, as compared with the common A-L-G haplotype, and was associated with an odds ratio for early-onset diabetes (age at diagnosis </=45 years) of 3.75 (95% CI 1.65-8.56, P = 0.002). 15677519 2005