|
HYPERAPOBETALIPOPROTEINEMIA, SUSCEPTIBILITY TO
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
We suggest that the PPARA L162V polymorphism may have diverse effects on serum lipids and CHD risk depends on the presence of T2DM.
|
23583468 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
According to our study, the L162V SNP does not have a strong impact on the pathogenesis of type 2 diabetes or obesity.
|
18726867 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
In conclusion, in a relative large-scale study of middle-aged whites we found no evidence of association between the PPARalpha Leu162Val polymorphism and obesity or type 2 diabetes.
|
17129741 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
We examined association between three PPARalpha gene polymorphisms (an A-->C variant in intron 1, the L162V variant, and the intron 7 G-->C variant) and age at diagnosis of type 2 diabetes in 912 Caucasian type 2 diabetic subjects.
|
15677519 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association between the PPARalpha L162V polymorphism, plasma lipoprotein levels, and atherosclerotic disease in patients with diabetes mellitus type 2 and in nondiabetic controls.
|
15199365 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
A polymorphism, L162V, in the peroxisome proliferator-activated receptor alpha (PPARalpha) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitus.
|
11409711 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
We subsequently screened a sample of 121 patients newly diagnosed with type 2 diabetes and their age and sex-matched nondiabetic controls, recruited from the Saguenay-Lac-St-Jean region of Northeastern Quebec, for the presence of the L162V mutation by a PCR-RFLP based method.
|
10828087 |
2000 |
|
Obesity
|
|
0.060 |
GeneticVariation
|
BEFREE |
GMDR analysis indicated a significant two-locus model (p=0.0107) involving rs1800206 and abdominal obesity, indicating a potential interaction among rs1800206 and abdominal obesity.
|
26671228 |
2016 |
|
Obesity
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study aimed to investigate the association of peroxisome proliferator-activated receptor (PPAR) genes PPARα L162V, PPARγ2 C161T and PPARδ T294C single nucleotide polymorphisms (SNPs) with obesity and metabolic syndrome (Met-S) in a multi-ethnic population in Kampar, Malaysia.
|
26673968 |
2015 |
|
Obesity
|
|
0.060 |
GeneticVariation
|
BEFREE |
According to our study, the L162V SNP does not have a strong impact on the pathogenesis of type 2 diabetes or obesity.
|
18726867 |
2009 |
|
Obesity
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, in a relative large-scale study of middle-aged whites we found no evidence of association between the PPARalpha Leu162Val polymorphism and obesity or type 2 diabetes.
|
17129741 |
2007 |
|
Obesity
|
|
0.060 |
GeneticVariation
|
BEFREE |
L162V was not associated with obesity, type 2 diabetes mellitus, hypercholesterolemia, or hypertriglyceridemia.
|
16297361 |
2005 |
|
Obesity
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study examined the effect a polymorphism (L162V) in the gene for peroxisome proliferator activated receptor (PPAR) alpha in the development of non-insulin-dependent diabetes mellitus (type 2 DM), obesity and hyperlipidaemia.
|
11409711 |
2001 |
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
We genotyped the Leu162Val polymorphism in 1383 patients with type 2 diabetes and 4401 control subjects with normal glucose tolerance (NGT) without showing any association between diabetes and genotype.
|
17129741 |
2007 |
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the placebo group, the G (162V) allele of rs1800206 increased the risk for diabetes by 1.9-fold (95% CI 1.05-3.58) and was associated with elevated levels of plasma glucose and insulin.
|
17317762 |
2007 |
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
The effect of the L162V polymorphism at the PPARA locus on CV risk depends on the presence of DM/IR.
|
16221474 |
2006 |
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
Overall, the PPARalpha haplotype signficantly influenced age at diagnosis (P = 0.027), with the C-L-C and C-V-C haplotypes (intron 1-L162V-intron 7) accelerating onset of diabetes by 5.9 (P = 0.02) and 10 (P = 0.03) years, respectively, as compared with the common A-L-G haplotype, and was associated with an odds ratio for early-onset diabetes (age at diagnosis </=45 years) of 3.75 (95% CI 1.65-8.56, P = 0.002).
|
15677519 |
2005 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results suggested that PPAR-alpha intron 7G/C and L162V, PPAR-delta +294T/C and PPAR-gamma C161T polymorphisms could affect CHD susceptibility, and C161T polymorphism might have different effects on CHD and ACS.
|
27512842 |
2016 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
This study aimed to investigate the association of peroxisome proliferator-activated receptor (PPAR) genes PPARα L162V, PPARγ2 C161T and PPARδ T294C single nucleotide polymorphisms (SNPs) with obesity and metabolic syndrome (Met-S) in a multi-ethnic population in Kampar, Malaysia.
|
26673968 |
2015 |
|
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
When the most common haplotype L-G (established by r</span>s1800206, rs4253778) was treated as the reference group, the V-G haplotype was associated with dyslipidemia (P < 0.001), higher TC and TG levels (P < 0.01).
|
24460649 |
2014 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
We suggest that the PPARA L162V polymorphism may have diverse effects on serum lipids and CHD risk depends on the presence of T2DM.
|
23583468 |
2013 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
The frequency distribution of rare alleles for PPARα (L162V) and PPARγ (P12A and H449H) was compared using the chi square test in 363 HIV-1-infected patients classified according to the presence or absence of the metabolic syndrome after 48 months of follow-up on their first PI-containing regimen.
|
21877956 |
2012 |
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
We genotyped the Leu162Val polymorphism in 1383 patients with type 2 diabetes and 4401 control subjects with normal glucose tolerance (NGT) without showing any association between diabetes and genotype.
|
17129741 |
2007 |
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the placebo group, the G (162V) allele of rs1800206 increased the risk for diabetes by 1.9-fold (95% CI 1.05-3.58) and was associated with elevated levels of plasma glucose and insulin.
|
17317762 |
2007 |