|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive iron absorption, fatigue, diabetes, arthritis, and liver disease, especially in men.
|
30657865 |
2019 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, cirrhosis in HFE p.C282Y homozygotes is significantly associated with age, diabetes, daily alcohol intake, and iron removed by phlebotomy, taking into account the effect of other variables.
|
30145563 |
2018 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Risk Factors for Insulin Resistance, Metabolic Syndrome, and Diabetes in 248 HFE C282Y Homozygotes Identified by Population Screening in the HEIRS Study.
|
26771691 |
2016 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
CONCLUSIONS In nonscreening hemochromatosis probands with HFE C282Y homozygosity, a heritable factor(s) increases the risk of diabetes diagnosed before hemochromatosis.
|
23990522 |
2014 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C282Y variant was not significantly associated with diabetes risk.
|
22908207 |
2012 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The mutation C282Y was not associated with diabetes or its chronic complications.
|
20097100 |
2011 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
We determined the prevalence of HFE mutations (C282Y and H63D) in the Tasmanian CF population and assessed the relationship to systemic iron stores, Pseudomonas aeruginosa infection, lung disease severity and prevalence of diabetes.
|
20199637 |
2010 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
All other common HFE genotypes--including C282Y-H63D compound heterozygosity--are not associated with significant biochemical and clinical expression in the absence of comorbid factors (e.g., alcohol, diabetes or steatohepatitis).
|
19072401 |
2008 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The mean serum ferritin concentration was greater (P < 0.0001) in women with diabetes than in those without diabetes for HFE genotypes except C282Y/C282Y and C282Y/H63D.
|
16936157 |
2006 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of 4,245 case and 5,982 control subjects indicated a null association of C282Y with diabetes risk, whereas carriers of H63D or the compound heterozygotes had marginally increased risk (odds ratio [OR] 1.11 [95% CI 1.00-1.25] and 1.60 [0.99-2.60], respectively).
|
16306377 |
2005 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Younger ages of onset of diabetes as well as a longer duration of the disease were detected in patients carrying at least one C282Y allele (p = 0.007).
|
15347835 |
2004 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele frequencies of C282Y and H63D did not differ between diabetic and control groups nor among subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes.
|
12148086 |
2002 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Different studies investigating the association of C282Y heterozygocity with morbidity have given conflicting results, as is exemplified by extrahepatic cancers, cardiovascular diseases, alcoholic liver disease, and diabetes.
|
12324192 |
2002 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
In patients with clinical hemochromatosis, the frequency of diabetes ranges from 20 to 50%, and the heterozygosity for the C282Y mutation in the HFE gene might be associated with an increased risk for diabetes.
|
11423500 |
2001 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
One of the 220 patients (0.45%) with diabetes was homozygous for the HFE 845A (C282Y) mutation and 25 (11.3%) were heterozygous for the same mutation, of whom 3 (1.3%) were compound heterozygotes also carrying the HFE 187G (H63D) mutation.
|
10695662 |
2000 |