|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Non-invasive assessment of liver fibrosis in C282Y homozygous HFE hemochromatosis.
|
25495562 |
2015 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes.
|
24556216 |
2014 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis.
|
17680648 |
2007 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, glucose intolerance may be important risk factor for the development of hepatic fibrosis in subjects with the C282Y/H63D HFE genotype.
|
16584391 |
2006 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A minimum of .66% C282Y homozygotes have liver fibrosis.
|
16797244 |
2006 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
For C282Y heterozygous patients, the odds ratios for marked inflammatory activity (A2-4) and advanced liver fibrosis or cirrhosis (F2-4) are 4.9 and 4.6, respectively, compared with patients carrying homozygous wild-type alleles.
|
15287851 |
2004 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Other recent evidence indicates that the prevalence of HFE gene mutations is increased in chronic viral hepatitis and that patients with chronic hepatitis C harboring especially the C282Y mutation are more likely to suffer from advanced hepatic fibrosis or cirrhosis and to do so at younger ages.
|
12957298 |
2003 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals.
|
12586300 |
2003 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients carrying C282Y had higher mean hepatic iron concentrations (P=0.02), hepatic iron indices (P<=0.0001), and hepatic fibrosis scores (P=0.01).
|
12445428 |
2002 |
|
Fibrosis, Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Those with C282Y mutations had significantly more hepatic fibrosis than those without (p<0.05).
|
10488699 |
1999 |