rs1800629, TNF

N. diseases: 169
Disease: Systemic Inflammatory Response Syndrome ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Systemic Inflammatory Response Syndrome
CUI: C0242966
Disease: Systemic Inflammatory Response Syndrome
0.010 GeneticVariation BEFREE Carriage of the TNF rs1800629 A allele was associated with higher TNF-alpha serum concentrations on the first day after trauma and during follow-up (two-sided p = 5.0 x 10(-5)), with development of sepsis syndrome (odds ratio 7.14, two-sided p = 1.2 x 10(-6); external validation sample [n = 76]: odds ratio 3.3, one-sided p = .03), and with fatal outcome (odds ratio 7.65, two-sided p = 1.9 x 10(-6)). 18434886 2008