|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, we genotyped four polymorphisms in genes encoding two immune system regulatory proteins (CTLA-4 rs231775 and CD28 rs3116496), interleukin-6 (IL6 rs1800795) and transforming growth factor-β (TGFB1 rs1800470) in 513 schizophrenia patients and 374 controls.
|
28673752 |
2018 |
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results imply that the IL6 rs1800795 CC homozygosity may play a rather unfavourable role in RA.
|
30054992 |
2018 |
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis.
|
28010120 |
2017 |
|
Rheumatic Heart Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the associations of 8 selected polymorphisms in seven inflammatory genes: IL-6 [rs1800795G/C], IL-10 [rs1800896G/A], TNF-A [rs1800629G/A], IL-1β [rs2853550C/T], IL-1VNTR [rs2234663], TGF-β1 [rs1800469C/T]; [rs1982073T/C], and CTLA-4 [rs5742909C/T] with RHD risk.
|
27118427 |
2016 |
|
Retinal Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our study was to determine an association between the -174G>C IL-6 polymorphism (rs1800795) and occurrence of retinopathy and nephropathy in type 1 diabetes mellitus (T1DM) patients.
|
19542902 |
2009 |
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study of 406 patients with psoriasis and 203 healthy controls was to evaluate the association between the IL6 -174G>C (rs1800795) polymorphism and psoriasis susceptibility, as well as treatment efficacy.
|
25357087 |
2015 |
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study aims to assess whether the association between the non-susceptibility allelic variants of IL12B single-nucleotide polymorphism (SNPs) rs3212227 and rs6887695, IL23R SNPs rs11209026 and rs7530511, IL6 SNP rs1800795 and HLA-Cw6 could be correlated with decreased risk for psoriasis.
|
24140476 |
2014 |
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)].
|
24446297 |
2014 |
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression.
|
29848725 |
2018 |
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001).
|
30854108 |
2019 |
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
|
19267250 |
2009 |
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)).
|
30345492 |
2019 |
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men.
|
28296724 |
2017 |
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer.
|
26535651 |
2015 |
|
Proliferative vitreoretinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Differences in genotype distributions between patients with RRD with or without PVR were detected in rs1800795 (IL6) (P = 0.04), rs1800871 (in the vicinity of the IL10) (P = 0.034), and rs1800471 (TGFB1) (P = 0.032).
|
30807515 |
2019 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
Having a C allele of the rs1800796 IL6 polymorphisms and the GG genotype of the rs1800795 IL6 polymorphisms was associated with a statistically significantly reduced the risk of colon (OR 0.76 95% CI 0.57, 1.00), but not rectal (OR 1.49 95% CI 1.02,2.16) cancer.
|
17694420 |
2007 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
To date, several association studies examining rs1800795 allele frequency and disease risk have reported seemingly conflicting results ranging from no association to association with either the major or minor allele across a spectrum of conditions, including cancer and autoimmune, cardiovascular, infectious, and metabolic diseases.
|
26578807 |
2015 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
Simultaneously, rs1800795 and rs1800796 were associated with a significantly higher risk of cancer in Asia and Caucasian, rs1800797 was associated with a significantly risk of cancer in Caucasian but not in Asia.
|
29552316 |
2018 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer.
|
29842912 |
2018 |
|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The risk allele frequencies (RAFs) of rs1800795 <i>(IL6)</i> and rs187238 <i>(IL18)</i> cytokine gene promoter SNPs were significantly higher in the PCAD cases as compared with the controls.
|
27559091 |
2017 |
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although our nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals.
|
31291232 |
2019 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results suggested that the IL-6 rs1800795</span> polymorphism is a protective factor for PCOS susceptibility.
|
30024552 |
2018 |
|
Pneumonia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In intensive care unit patients, the TNF-α -308A allele and the IL-6 rs1800795 allele variants were susceptibility risk factors for septic shock induced by pneumonia.
|
26025100 |
2015 |
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein.
|
28651253 |
2017 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The -174G>C (rs1800795) single nucleotide polymorphism (SNP) in the promoter of the interleukin-6 (IL6) gene and the 1730G>A (rs4986938) SNP in the estrogen receptor beta (ESR2) may influence the risk of Parkinson's disease (PD).
|
22155094 |
2012 |