|
peak expiratory flow (procedure)
|
|
0.700 |
GeneticVariation
|
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Forced expiratory volume function
|
|
0.700 |
GeneticVariation
|
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Forced expiratory volume function
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
|
28166213 |
2017 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present meta-analysis demonstrated that C79G and C491T polymorphism may be a defensive factor for asthma, while A46G polymorphism may be a risk factor for asthma among the Caucasian population.
|
31115019 |
2019 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In south Indian population, the ADRB2 Thr164Ile polymorphism may not form susceptible variant to develop asthma, however, it can form a predictive maker for bronchodilator (Salbutamol) response in severe asthmatics.
|
27450915 |
2016 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Identification of Small Molecule as a High Affinity β2 Agonist Promiscuously Targeting Wild and Mutated (Thr164Ile) β 2 Adrenergic Receptor in the Treatment of Bronchial Asthma.
|
27174812 |
2016 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
One of the variants was a highly functional nonsynonymous variant in ADRB2 (rs1800888), which was also nominally associated with asthma (p = 0.027) and active asthma (p = 0.013) among European Americans with severe RSV bronchiolitis without including the ESP.
|
26587832 |
2015 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD).
|
22075484 |
2012 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The less common Thr164Ile polymorphism (rs1800888, Ile allele frequency 1.5%) was not a major predictor of either frequency or prognosis of asthma.
|
16935688 |
2006 |
|
Congestive heart failure
|
|
0.040 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression.
|
20803192 |
2010 |
|
Congestive heart failure
|
|
0.040 |
GeneticVariation
|
BEFREE |
Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly and Thr164Ile were suggested to have an effect in heart failure.
|
19886995 |
2009 |
|
Congestive heart failure
|
|
0.040 |
GeneticVariation
|
BEFREE |
The prevalence of the hypofunctional Thr164Ile</span>-beta(2)AR variant and the frequency of the Ile164-allele were almost identical in CHF-patients, who had undergone HTX, with those in patients with stable CHF or in healthy controls.
|
16783489 |
2006 |
|
Congestive heart failure
|
|
0.040 |
GeneticVariation
|
BEFREE |
Of particular importance, the Thr164Ile polymorphism, which is found in approximately 4% of humans, shows decreased receptor signaling, blunted cardiac response when expressed in transgenic mice, and is associated with a decreased survival rate in patients with congestive heart failure.
|
11222464 |
2001 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Eighty-two patients with COPD and 17 healthy smokers were recruited and screened for ADRb2 (T164I and R175R), for CHRM2 (rs1824024) and for CHRM3 (-513C/A and -492C/T).
|
26633752 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Finally, we found that the rare Thr164Ile polymorphism in ADRB2 was associated with reduced lung function and risk of COPD, whereas the more common Gly16Arg and Gln27Glu were not.
|
25186548 |
2014 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest tha</span>t ADRB2 Thr164</span>Ile is associated with reduced lung function and increased risk of COPD in the general population.
|
22075484 |
2012 |
|
Heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression.
|
20803192 |
2010 |
|
Heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly and Thr164Ile were suggested to have an effect in heart failure.
|
19886995 |
2009 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
No other significant associations were observed between ADRB1 (rs1801252, rs1801253), ADRB2 (rs1042713, rs1800888) polymorphisms and cardiovascular events or all-cause mortality in CAD patients.
|
30668166 |
2019 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
|
0.010 |
GeneticVariation
|
BEFREE |
One of the variants was a highly functional nonsynonymous variant in ADRB2 (rs1800888), which was also nominally associated with asthma (p = 0.027) and active asthma (p = 0.013) among European Americans with severe RSV bronchiolitis without including the ESP.
|
26587832 |
2015 |
|
Bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
One of the variants was a highly functional nonsynonymous variant in ADRB2 (rs1800888), which was also nominally associated with asthma (p = 0.027) and active asthma (p = 0.013) among European Americans with severe RSV bronchiolitis without including the ESP.
|
26587832 |
2015 |
|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four ADRB2 single nucleotide polymorphisms (rs1042711, rs1042713, rs1042714 and rs1800888) were genotyped in 953 children from the prospective birth cohort 'Environment and Childhood Asthma' study and analysed for association with flow-volume parameters at birth (tidal breathing) and at 10 years of age (maximally forced), stratified by environmental exposures.
|
23463918 |
2013 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of IHD amongst women in the general population.
|
21883537 |
2012 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that ADRB2rs1800888(Thr164Ile) rare vs. common homozygotes are not significantly associated with an increase in BMI measured continuously but may be associated with an increased risk of obesity.
|
22466342 |
2012 |