rs1801058, GRK4

N. diseases: 4
Disease: Hypertensive disease ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.040 GeneticVariation BEFREE There were 4 NSV of GRK4 (R65L, A116T, A142V, V486A): at least one was found in all 9 patients; 3 were previously described and associated with hypertension. 28052878 2017
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.040 GeneticVariation BEFREE Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4. 26134571 2015
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.040 GeneticVariation BEFREE This meta-analysis suggested that rs1801058 polymorphism in the GRK4 gene was associated with hypertension in East Asians and Europeans. 22639547 2012
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.040 GeneticVariation BEFREE Constitutively activated GRK4 gene variants (R65L, A142V, and A486V), by themselves or by their interaction with other genes involved in blood pressure regulation, are associated with essential hypertension and/or salt-sensitive hypertension in several ethnic groups. 20153824 2010