Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
Association of 677 C>T (rs1801133) and 1298 A>C (rs1801131) polymorphisms in the MTHFR gene and breast cancer susceptibility: a meta-analysis based on 57 individual studies.
|
24945727 |
2014 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the independent and the combined effects of two commonly occurring polymorphisms, MTHFR 677C>T (rs1801133) and MTHFR 1298A>C (rs1801131), as well as their interaction with the use of hormone replacement therapy (HRT), to determine their potential contribution to breast cancer risk.
|
21461582 |
2011 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that the MTHFR Glu429Ala polymorphism may be not associated with breast cancer development.
|
23393023 |
2013 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
MTHFR-rs1801131-CC genotype was associated with sporadic BC.
|
29544444 |
2018 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs1801131) SNPs and if the polymorphisms per se were associated with breast cancer.
|
19336565 |
2009 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
MTHFR-rs1801131-CC genotype was associated with sporadic BC.
|
29544444 |
2018 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed and their joint effects with individual age- and estrogen-related factors on breast cancer risk were discussed.
|
25075036 |
2014 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Association of 677 C>T (rs1801133) and 1298 A>C (rs1801131) polymorphisms in the MTHFR gene and breast cancer susceptibility: a meta-analysis based on 57 individual studies.
|
24945727 |
2014 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Haplotype analysis also showed that MTHFR CACCAA and AGTCAC haplotypes (rs12121543-rs13306553-rs9651118-rs1801133-rs4846048-rs1801131) had significant reduced risk of breast cancer (adjusted OR = 0.70, 95 % CI 0.58-0.86; adjusted OR = 0.57, 95 % CI 0.40-0.80) compared with CATTAA haplotype.
|
25566964 |
2015 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
Haplotype analysis also showed that MTHFR CACCAA and AGTCAC haplotypes (rs12121543-rs13306553-rs9651118-rs1801133-rs4846048-rs1801131) had significant reduced risk of breast cancer (adjusted OR = 0.70, 95 % CI 0.58-0.86; adjusted OR = 0.57, 95 % CI 0.40-0.80) compared with CATTAA haplotype.
|
25566964 |
2015 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the association of polymorphisms in MTHFR (rs1801133 and rs1801131) and MTR (rs1805087) with breast cancer risk and their interaction with alcohol consumption in a case-control study--the Western New York Exposures and Breast Cancer study.
|
19706843 |
2009 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the association of polymorphisms in MTHFR (rs1801133 and rs1801131) and MTR (rs1805087) with breast cancer risk and their interaction with alcohol consumption in a case-control study--the Western New York Exposures and Breast Cancer study.
|
19706843 |
2009 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that the MTHFR Glu429Ala polymorphism may be not associated with breast cancer development.
|
23393023 |
2013 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs1801131) SNPs and if the polymorphisms per se were associated with breast cancer.
|
19336565 |
2009 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed and their joint effects with individual age- and estrogen-related factors on breast cancer risk were discussed.
|
25075036 |
2014 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the independent and the combined effects of two commonly occurring polymorphisms, MTHFR 677C>T (rs1801133) and MTHFR 1298A>C (rs1801131), as well as their interaction with the use of hormone replacement therapy (HRT), to determine their potential contribution to breast cancer risk.
|
21461582 |
2011 |
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The MTHFR rs1801133 polymorphism was not associated with the prognosis of patients with CRC; however, rs1801131 may be associated with the prognosis of patients with CRC.
|
31330573 |
2019 |
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR gene (rs1801133 and rs1801131) and in the MTRR gene (rs1801394, rs1532268, rs162036, and rs10380) with the risk for colorectal cancer in 666 patients and 1377 controls from the Czech Republic.
|
21211571 |
2011 |
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We genotyped MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) for 498 CRC patients treated with 5-FU-based chemotherapy after receiving surgery.
|
28044213 |
2017 |
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Three SNPs were shown to increase CRC risk: PTGS1 c.639C>A (p.Gly213Gly), IL8 c.-352T>A, and MTHFR c.1286A>C (p.Ala429Glu).
|
18992148 |
2008 |
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present meta-analysis showed that rs1801133 and rs1801131 might be CRC susceptibility variants in Americans and Australians and rs1801133 in Brazilians and Japanese.
|
25823789 |
2015 |
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals.
|
29599316 |
2018 |
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed to examine the extent of their associations with childhood ALL susceptibility and to discuss the MTHFR genotypic contribution to childhood ALL risk among different populations.
|
25793509 |
2015 |
Adult Acute Lymphocytic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63).
|
27996344 |
2017 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multiple Cox regression analyses revealed an association of minimal residual disease (hazard ratio 7.3; P < .001) and methylenetetrahydrofolate reductase rs1801131 (hazard ratio 3.1; P = .015) with event-free survival in the ALL-BFM 2000 study population.
|
23652803 |
2013 |