Down Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we determined polymorphisms of MTHFR A222V (677C > T), MTHFR E429A (1298A > C), MTRR I22M (66A > G), MTR D919G (2756A > G), and CBS 844ins68 and total plasma homocysteine levels (tHcy) among 154 mothers of children with Down syndrome (DS) and 158 control mothers from Brazil.
|
15889417 |
2005 |
Complete Trisomy 21 Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we determined polymorphisms of MTHFR A222V (677C > T), MTHFR E429A (1298A > C), MTRR I22M (66A > G), MTR D919G (2756A > G), and CBS 844ins68 and total plasma homocysteine levels (tHcy) among 154 mothers of children with Down syndrome (DS) and 158 control mothers from Brazil.
|
15889417 |
2005 |
Bipolar Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls.
|
18513846 |
2008 |
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Three SNPs were shown to increase CRC risk: PTGS1 c.639C>A (p.Gly213Gly), IL8 c.-352T>A, and MTHFR c.1286A>C (p.Ala429Glu).
|
18992148 |
2008 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs1801131) SNPs and if the polymorphisms per se were associated with breast cancer.
|
19336565 |
2009 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs1801131) SNPs and if the polymorphisms per se were associated with breast cancer.
|
19336565 |
2009 |
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the association of polymorphisms in MTHFR (rs1801133 and rs1801131) and MTR (rs1805087) with breast cancer risk and their interaction with alcohol consumption in a case-control study--the Western New York Exposures and Breast Cancer study.
|
19706843 |
2009 |
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the association of polymorphisms in MTHFR (rs1801133 and rs1801131) and MTR (rs1805087) with breast cancer risk and their interaction with alcohol consumption in a case-control study--the Western New York Exposures and Breast Cancer study.
|
19706843 |
2009 |
Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
There was no evidence of rs1801131 (A1298C) affecting age of onset in schizophrenia.
|
19746410 |
2010 |
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
MTHFR c.677C>T (p.A222V) and c.1298A>C (p.E429A), in 138 patients with clinically definite multiple sclerosis of relapsing-remitting course and 138 age- and gender-matched healthy controls.
|
19854238 |
2010 |
OTOFACIOCERVICAL SYNDROME 1
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the effects of maternal riboflavin intake and two MTHFR polymorphisms (677C>T; Ala222Val and 1298A>C; Glu429Ala substitutions) on the biomarkers of the homocysteine pathway, and investigate the risk of having offspring with an orofacial cleft (OFC).
|
19935819 |
2010 |
Orofacial cleft
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the effects of maternal riboflavin intake and two MTHFR polymorphisms (677C>T; Ala222Val and 1298A>C; Glu429Ala substitutions) on the biomarkers of the homocysteine pathway, and investigate the risk of having offspring with an orofacial cleft (OFC).
|
19935819 |
2010 |
OROFACIAL CLEFT 1
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the effects of maternal riboflavin intake and two MTHFR polymorphisms (677C>T; Ala222Val and 1298A>C; Glu429Ala substitutions) on the biomarkers of the homocysteine pathway, and investigate the risk of having offspring with an orofacial cleft (OFC).
|
19935819 |
2010 |
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with lung cancer susceptibility, and discussed their joint effects with individual habits on lung cancer risk.
|
20065319 |
2010 |
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with lung cancer susceptibility, and discussed their joint effects with individual habits on lung cancer risk.
|
20065319 |
2010 |
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with lung cancer susceptibility, and discussed their joint effects with individual habits on lung cancer risk.
|
20065319 |
2010 |
Primary central nervous system lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, for the methylenetetrahydrofolate reductase (MTHFR) c.1298A > C (E429A) polymorphism the mutated C-allele was found more frequently among PCNSL patients than among population controls (P = 0.026; OR = 1.57; 1.05-2.34).
|
20237949 |
2010 |
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
While rs1801131A/C genetic polymorphism is associated with the clinical response, rs1801133C/T and rs2274976A/G genetic polymorphisms are associated with MTX-related AEs in the treatment of RA.
|
20863444 |
2010 |
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the association and interaction of genotypic polymorphisms in MTHFR and lifestyle factors with prostate cancer in Taiwan, we investigated two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), analyzed the association of specific genotypes with prostate cancer susceptibility, and discussed their joint effects with individual habits on prostate cancer risk.
|
20944139 |
2010 |
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the association and interaction of genotypic polymorphisms in MTHFR and lifestyle factors with prostate cancer in Taiwan, we investigated two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), analyzed the association of specific genotypes with prostate cancer susceptibility, and discussed their joint effects with individual habits on prostate cancer risk.
|
20944139 |
2010 |
Mental Retardation
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis found statistically significant difference in allele and genotype frequencies between cases with both CP and MR (CP + MR) compared with both CP-only cases and controls at rs4846049, rs1476413 and rs1801131.
|
20962791 |
2011 |
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis found statistically significant difference in allele and genotype frequencies between cases with both CP and MR (CP + MR) compared with both CP-only cases and controls at rs4846049, rs1476413 and rs1801131.
|
20962791 |
2011 |
Intellectual Disability
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis found statistically significant difference in allele and genotype frequencies between cases with both CP and MR (CP + MR) compared with both CP-only cases and controls at rs4846049, rs1476413 and rs1801131.
|
20962791 |
2011 |
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR gene (rs1801133 and rs1801131) and in the MTRR gene (rs1801394, rs1532268, rs162036, and rs10380) with the risk for colorectal cancer in 666 patients and 1377 controls from the Czech Republic.
|
21211571 |
2011 |
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR gene (rs1801133 and rs1801131) and in the MTRR gene (rs1801394, rs1532268, rs162036, and rs10380) with the risk for colorectal cancer in 666 patients and 1377 controls from the Czech Republic.
|
21211571 |
2011 |