Further subgroup analyses revealed that the rs1801131</span> polymorphism was significantly associated with the likelihood of HCC in Asians with both FEMs (recessive model: <i>P</i> < 0.0001, OR = 0.42, 95% CI 0.29-0.62; allele model: <i>P</i> = 0.004, OR =1.20, 95% CI 1.06-1.35) and random-effect models (recessive model: <i>P</i> = 0.002, OR = 0.47, 95% CI 0.29-0.75).
This study demonstrated that MTHFR polymorphism was associated with HCC occurrence and post-transplant HCC recurrence. rs1801131 mutation A to C is a valuable molecular biomarker for predicting HCC occurrence in Chinese Han population.