|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This study demonstrated that MTHFR polymorphism was associated with HCC occurrence and post-transplant HCC recurrence. rs1801131 mutation A to C is a valuable molecular biomarker for predicting HCC occurrence in Chinese Han population.
|
29185200 |
2018 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63).
|
27996344 |
2017 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63).
|
27996344 |
2017 |
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63).
|
27996344 |
2017 |
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed to examine the extent of their associations with childhood ALL susceptibility and to discuss the MTHFR genotypic contribution to childhood ALL risk among different populations.
|
25793509 |
2015 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed to examine the extent of their associations with childhood ALL susceptibility and to discuss the MTHFR genotypic contribution to childhood ALL risk among different populations.
|
25793509 |
2015 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed to examine the extent of their associations with childhood ALL susceptibility and to discuss the MTHFR genotypic contribution to childhood ALL risk among different populations.
|
25793509 |
2015 |
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
MTHFR SNPs rs1801131 and rs1801133 are unlikely to have a clinically meaningful effect on the first 6 months of MTX treatment in early RA.
|
24624914 |
2014 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multiple Cox regression analyses revealed an association of minimal residual disease (hazard ratio 7.3; P < .001) and methylenetetrahydrofolate reductase rs1801131 (hazard ratio 3.1; P = .015) with event-free survival in the ALL-BFM 2000 study population.
|
23652803 |
2013 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multiple Cox regression analyses revealed an association of minimal residual disease (hazard ratio 7.3; P < .001) and methylenetetrahydrofolate reductase rs1801131 (hazard ratio 3.1; P = .015) with event-free survival in the ALL-BFM 2000 study population.
|
23652803 |
2013 |
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multiple Cox regression analyses revealed an association of minimal residual disease (hazard ratio 7.3; P < .001) and methylenetetrahydrofolate reductase rs1801131 (hazard ratio 3.1; P = .015) with event-free survival in the ALL-BFM 2000 study population.
|
23652803 |
2013 |
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G > A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A > C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA.
|
22927710 |
2012 |
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
While rs1801131A/C genetic polymorphism is associated with the clinical response, rs1801133C/T and rs2274976A/G genetic polymorphisms are associated with MTX-related AEs in the treatment of RA.
|
20863444 |
2010 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
The most significant phosSNPs for SBP, DBP, CAD and IS were rs1801131 in MTHFR, rs3184504 in SH2B3, rs35212307 in WDR12 and rs3184504 in SH2B3, respectively.
|
31456518 |
2019 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the associations of MTHFR (rs1801133, rs1801131, rs9651118), TCN2 (rs117353193) and RNF213 (rs9916351) with hypertension and blood pressure (BP).
|
31815282 |
2019 |
|
Attention deficit hyperactivity disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
MTHFR rs1801131, MTR rs1805087 and BHMT rs3733890 also showed association with ADHD index.
|
29407547 |
2018 |
|
Hyperhomocysteinemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of hyperhomocysteinemia associated MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) was done by PCR-restriction fragment length polymorphism.
|
29600437 |
2018 |
|
Hyperhomocysteinemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The MTHFR rs1801133 CT genotype, TT genotype and T allele; the MTHFR rs1801131 AC genotype, CC genotype and C allele; the MTRR rs1801394 GA genotype, GG genotype and G allele; and the MTRR rs162036 AG genotype and AG+GG genotypes were associated with the efficacy of folic acid therapy for HHcy (P<0·05).
|
29644956 |
2018 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our overall analyses suggested that <i>MTRR</i> rs1801394, <i>MTRR</i> rs1532268, <i>MTHFR</i> rs1801131 and <i>MTHFR</i> rs1801133 polymorphisms were all significantly associated with the risk of CHD in certain genetic models.
|
30333252 |
2018 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Previous studies have investigated the association between MTHFR A1298C (rs1801131) polymorphism and susceptibility to Alzheimer's disease (AD).
|
28281392 |
2017 |
|
Adult Meningioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
|
28915669 |
2017 |
|
Meningioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
Adult Meningioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
Meningioma, benign, no ICD-O subtype
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
Meningioma, benign, no ICD-O subtype
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
|
28915669 |
2017 |