|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 × 10-17), serum folate (P = 2.82 × 10-11), and plasma total homocysteine (P = 1.26 × 10-19) concentrations.
|
30339177 |
2018 |
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.
|
23696881 |
2013 |
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
|
23824729 |
2013 |
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.
|
23696881 |
2013 |
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
|
23824729 |
2013 |
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
|
20031578 |
2009 |
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
|
20031578 |
2009 |
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
The common mutations found to be associated with schizophrenia and MTHFR are A222V, E429A, and R594Q.
|
28427558 |
2017 |
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in schizophrenia.
|
23353103 |
2013 |
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic variant in methylenetetrahydrofolate reductase (MTHFR 677C>T, rs1801133) that increases risk for schizophrenia and that has been specifically associated with increased perseverative errors among patients.
|
21980405 |
2011 |
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
|
22037552 |
2011 |
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
However, since our meta-analysis results demonstrated strong support for association of rs1801133 with schizophrenia, further replication studies based on a gene-wide approach need to be considered.
|
20692813 |
2010 |
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
Among the Scandinavian patients the functional MTHFR SNP rs1801133 (C677T) significantly affected age at onset of schizophrenia in a dose-dependent manner (P = 0.0015), with lower age of onset with increasing numbers of the mutant T-allele.
|
19746410 |
2010 |
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |
|
RDW - Red blood cell distribution width result
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Red cell distribution width determination
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Folic acid measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
We validated that rs1801133 in MTHFR was significantly involved in serum folate (P = 4.21 × 10<sup>-19</sup>).
|
29953918 |
2018 |
|
Folic acid measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 × 10-17), serum folate (P = 2.82 × 10-11), and plasma total homocysteine (P = 1.26 × 10-19) concentrations.
|
30339177 |
2018 |
|
VITAMIN B12 MEASUREMENT
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
19303062 |
2009 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis indicated that MTRR rs1801394, MTR rs1805087, and MTHFR rs1801133 polymorphisms could be used to identify individuals at high risk of developing BC.
|
31549463 |
2020 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis indicated that MTRR rs1801394, MTR rs1805087, and MTHFR rs1801133 polymorphisms could be used to identify individuals at high risk of developing BC.
|
31549463 |
2020 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR rs1801133 polymorphism was not associated with the prognosis of patients with CRC; however, rs1801131 may be associated with the prognosis of patients with CRC.
|
31330573 |
2019 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evaluation of the two polymorphisms rs1801133 in MTHFR and rs10811661 in CDKN2A/B in breast cancer.
|
30362613 |
2018 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evaluation of the two polymorphisms rs1801133 in MTHFR and rs10811661 in CDKN2A/B in breast cancer.
|
30362613 |
2018 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR rs1801133 T allele serves as a predictive marker for CRC risk and future studies with larger samples and functional evaluation are warranted to validate the current findings.
|
29599316 |
2018 |