|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
The association between rs1801157 genotypes (G/A) and BC risks was assessed by a multivariate logistic regression (MLR) analysis.
|
28929029 |
2017 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The association between rs1801157 genotypes (G/A) and BC risks was assessed by a multivariate logistic regression (MLR) analysis.
|
28929029 |
2017 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found that the CXCL12 G801A (rs1801157) polymorphism was associated with a significantly increased risk of breast cancer risk when all studies were pooled into the meta-analysis (codomiant model: AA versus GG, OR = 1.64, 95% CI = 1.16-2.33; GA versus GG, OR = 1.42, 95% CI = 1.18-1.71; dominant model: AA/GA versus GG, OR = 1.44, 95% CI = 1.21-1.72).
|
21643956 |
2012 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found that the CXCL12 G801A (rs1801157) polymorphism was associated with a significantly increased risk of breast cancer risk when all studies were pooled into the meta-analysis (codomiant model: AA versus GG, OR = 1.64, 95% CI = 1.16-2.33; GA versus GG, OR = 1.42, 95% CI = 1.18-1.71; dominant model: AA/GA versus GG, OR = 1.44, 95% CI = 1.21-1.72).
|
21643956 |
2012 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
However a significant difference was observed when CXCL12 mRNA relative expression was analyzed in breast cancer patients in accordance to the presence or absence of the CXCL12 rs1801157 allele A. Allele A breast cancer patients presented a mRNA CXCL12 expression about 2.1-fold smaller than GG breast cancer patients.
|
21592819 |
2011 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
However a significant difference was observed when CXCL12 mRNA relative expression was analyzed in breast cancer patients in accordance to the presence or absence of the CXCL12 rs1801157 allele A. Allele A breast cancer patients presented a mRNA CXCL12 expression about 2.1-fold smaller than GG breast cancer patients.
|
21592819 |
2011 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The CXCL12-3' G801A transition (rs1801157) has been associated with the incidence of breast cancer.
|
20406099 |
2010 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
The CXCL12-3' G801A transition (rs1801157) has been associated with the incidence of breast cancer.
|
20406099 |
2010 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Similarly, the SNP barcode of rs12812942-rs2228014-rs3025039 (CD4-CXCR4-VEGF) and rs12812942-rs3136685-rs2228014-rs1801157 (CD4- CCR7-CXCR4-CXCL12) with specific genotype patterns (AT-CC-CC and AT-AG-CC-GG) among three and four combinational SNPs were significantly low in breast cancer occurrence.
|
19196101 |
2009 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma.
|
19927352 |
2009 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma.
|
19927352 |
2009 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Similarly, the SNP barcode of rs12812942-rs2228014-rs3025039 (CD4-CXCR4-VEGF) and rs12812942-rs3136685-rs2228014-rs1801157 (CD4- CCR7-CXCR4-CXCL12) with specific genotype patterns (AT-CC-CC and AT-AG-CC-GG) among three and four combinational SNPs were significantly low in breast cancer occurrence.
|
19196101 |
2009 |
|
Neoplasm Metastasis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) genes may contribute to susceptibility to childhood ALL because they affect some important processes, such as metastasis regulation and tumor suppression.
|
23653000 |
2013 |
|
Neoplasm Metastasis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Expression of the CXCL12 (SNP rs1801157) polymorphisms GA/AA significantly correlated with distant metastasis (P=0.026), but not with prognosis.
|
21584490 |
2011 |
|
Neoplasm Metastasis
|
|
0.050 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphism (SNP) rs1801157 (previously known as CXCL12-A/SDF1-3'A) in the CXCL12 gene and the relative expression of mRNA CXCL12 in peripheral blood were assessed in breast cancer patients, since the chemokine CXCL12 and its receptor CXCR4 regulate leukocyte trafficking and many essential biological processes, including tumor growth, angiogenesis and metastasis of different types of tumors.
|
21592819 |
2011 |
|
Neoplasm Metastasis
|
|
0.050 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphism (SNP) rs1801157 (previously known as CXCL12-A/ stromal cell-derived factor-1 (SDF1)-3'A) in CXCL12/SDF1 gene was assessed in breast cancer, Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL), since the chemokine CXCL12, previously known as SDF1, and its receptor CXCR4 regulate leukocyte trafficking and many essential biological processes, including tumor growth, angiogenesis, and metastasis of different types of tumors.
|
19927352 |
2009 |
|
Neoplasm Metastasis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We were also unable to find a correlation between rs1801157 and different prognostic markers such as metastasis development or disease-free survival time.
|
17982648 |
2007 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
The <i>CXCL12</i> rs1801157 polymorphism is putatively associated with the risk of malignancy.
|
29760554 |
2018 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, this study suggested that the SDF-1 rs1801157 polymorphism may serve as a risk factor for cancer development among Asians, especially an increased risk of urologic and lung cancers.
|
27265091 |
2016 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
CXCL12 has been implicated in human carcinogenesis, but the association between the most-studied G801A polymorphism (rs1801157) and the risk of various cancers was reported with inconclusive results.
|
22939870 |
2012 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer.
|
21584490 |
2011 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
The <i>CXCL12</i> rs1801157 polymorphism is putatively associated with the risk of malignancy.
|
29760554 |
2018 |
|
Myocardial Infarction
|
|
0.030 |
GeneticVariation
|
BEFREE |
Taken together, the current findings suggest that the SDF1-rs1801157A/G gene variant may play an important role in relation to MI in this Iranian population.
|
28650670 |
2017 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, this study suggested that the SDF-1 rs1801157 polymorphism may serve as a risk factor for cancer development among Asians, especially an increased risk of urologic and lung cancers.
|
27265091 |
2016 |
|
Myocardial Infarction
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, our meta-analysis demonstrated that the rs1801157 polymorphism is not associated with the susceptibility to CHD but may be associated with a decreased risk of MI.
|
26133117 |
2015 |