rs1801274, FCGR2A

N. diseases: 46
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.040 GeneticVariation BEFREE The low affinity Fcγ receptor, FcγRIIA, harbors a common missense mutation, rs1801274 (G>A, Arg131His) that modifies binding affinity to human IgG2 and mouse IgG1 antibodies and is associated with increased risk of autoimmune disease. 29977032 2019
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.040 GeneticVariation BEFREE Association of FCGR2A rs1801274 polymorphism with susceptibility to autoimmune diseases: A meta-analysis. 27270653 2016
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.040 GeneticVariation BEFREE The Fc Gamma Receptor IIa (FcGRIIa) molecule is involved in the clearance of autoantibodies and a functional single nucleotide polymorphism (SNP), rs1801274, which has been shown to alter autoantibody clearance, has been associated with a number of autoimmune diseases (AIDs) including systemic lupus erythematosus and type 1 diabetes. 20148910 2010
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.040 GeneticVariation BEFREE In addition to the expected strong association with the major histocompatibility complex (MHC) region, we identified three new susceptibility loci: the immunoglobulin receptor gene FCGR2A (rs1801274, P = 1.56 x 10(-12)), a locus on chromosome 13q12 (rs17085007, P = 6.64 x 10(-8)) and the glycoprotein gene SLC26A3 (rs2108225, P = 9.50 x 10(-8)). rs1801274 is a nonsynonymous SNP of FCGR2A that is reported to have a critical effect on receptor binding affinity for IgG and to be associated with other autoimmune diseases. 19915573 2009