rs1801282, PPARG

N. diseases: 131
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE We investigated individual and combined associations of Pro12Ala and His447His polymorphisms of PPARγ with PCOS susceptibility and its related traits (hyperinsulinemia, hyperandrogenemia and lipid parameters) in Indian women. 23748472 2013
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE Pro12Ala, a missense mutation in exon 2 of PPARG, reduces transcriptional activity of PPARgamma2 and is shown to be associated with increased insulin sensitivity and protection from T2D. 20368233 2010
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE We studied the effect of the Pro12Ala polymorphism on the rates of whole-body, skeletal muscle, and subcutaneous adipose tissue glucose uptake (GU) in T2DM subjects, and the rates of hepatic GU in nondiabetic and T2DM subjects during hyperinsulinemia. 19303976 2009
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE The Pro12Ala polymorphism of the PPARgamma gene is associated with increased insulin sensitivity and lower hirsutism scores in PCOS women. 15853827 2005
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes. 12643137 2002
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE Our results suggest that the Pro12Ala polymorphism of the PPARgamma-2 gene promotes peripheral deposition of adipose tissue and increased insulin sensitivity for a given BMI. 12370112 2002
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE Among the genetic factors, a polymorphism (Pro12Ala) in the peroxisome proliferator-activated receptor (PPAR) gamma is associated with a reduced risk of type 2 diabetes mellitus and increased insulin sensitivity, primarily that of lipolysis. 11684868 2001
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE The Pro12Ala polymorphism in the PPAR-gamma2 gene has been associated with reduced transcriptional activity in vitro and increased insulin sensitivity in vivo. 11334419 2001
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.090 GeneticVariation BEFREE The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. 10382597 1999