rs1801282, PPARG

N. diseases: 131
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE In addition, the impact of total energy intake on obesity in Pro12Ala</span> carriers seemed to be stronger than that in the wild-type genotype carriers. 30122193 2018
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR). 28090739 2017
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE When T2D cohort was further stratified according to the obesity status, PPARγ2 (rs1801282) and FTO (rs9939609) showed association with T2D only in the obese diabetic group and ADIPOQ (rs16861194) showed no difference in risk of susceptibility to the disease. 26243686 2016
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Moreover, the combination of the rs2282440-SDC3T/T genotype with the rs1801282-peroxisome proliferator-activated receptor-gamma2 gene (PPARγ2) G carrier genotype was strongly associated with obesity (OR=6.77). 27515755 2016
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%. 27442659 2016
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The combined results showed that PPAR-γ Pro1</span>2Ala polymorphism was associated with the obesit</span>y risk (Ala vs. 25502405 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. 26185753 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Polymorphisms of the peroxisome proliferator-activated receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus. 25928419 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The PPARG rs1801282 SNP did not exhibit any significant association with obesity among the complete sample population. 25182148 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis. 26361038 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index. 24827746 2014
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE In the group with ACE DD genotype, those with PPARγ Pro12Ala or Ala12Ala genotype have greater odds for obesity (OR=9.98; 95% CI: 1.18-84.14, p=0.034). 24200052 2014
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Interaction between Pro12Ala polymorphism of PPARγ2 and diet on adiposity phenotypes. 25342491 2014
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity. 24969838 2014
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Concurrently, genotyping of the Pro12Ala polymorphism showed that obese subjects possess a significantly higher frequency of the Pro/Pro genotype than nonobese controls (90.5 vs 79.5%; P = 0.03), suggesting that this genotype is involved in an increased risk of obesity in the Tunisian population. 23315125 2013
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association. 22410809 2012
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Association between PPARγ2 Pro12Ala polymorphism and myocardial infarction and obesity in Han Chinese in Hohhot, China. 22653647 2012
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet. 22102511 2011
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations. 19805902 2009
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis. 19766907 2009
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Many studies have focused on the physiological parameters and genetic predisposition of subjects presenting both obesity and insulin resistance (IR) and it has been suggested that the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) Pro12Ala variant may contribute to the observed variability in insulin sensitivity. 19645740 2009
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin. 19733160 2009
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment. 17052804 2008
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARG; NCBI dbSNP rs1801282) has been associated with preservation of cognitive function, decreased risk of diabetes, and increased risk of obesity. 18280041 2008
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Beta3AR Trp64Arg and PPARgamma2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity, and there might be slight synergistic effects between this two gene loci, and further studies are necessary to confirm this finding. 17624182 2007