Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | The rs1801282 polymorphism may not be associated with genetic susceptibility to GDM in whites. | 29885389 | 2018 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | Several variants <i>PPARG2</i> rs1801282 (<i>C>G</i>); <i>PPARGC1A</i> rs8192678 (<i>C>T</i>); <i>TCF7L2</i> rs7903146 (<i>C>T</i>); <i>LDLR</i> rs2228671 (<i>C>T</i>); <i>MTHFR</i> rs1801133 (<i>C>T</i>); <i>APOA5</i> rs662799 (<i>T>C</i>); <i>GCKR</i> rs1260326 (<i>C>T</i>); <i>FTO</i> rs9939609 (<i>T>A</i>); <i>MC4R</i> rs17782313 (<i>T>C</i>) were genotyped in 168 pregnant Caucasian women with or without GDM by High Resolution Melting (HRM) analysis. | 28133617 | 2017 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | Association between the PPARγ Pro12Ala polymorphism and risk of gestational diabetes mellitus: a meta-analysis. | 27819738 | 2016 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | Overall GDM was associated with rs10830963(MTNR1B), rs7903146(TCF7L2), and rs1801278(IRS1), but only rs7903146(TCF7L2) and rs1801282(PPARG) were significant in Asian populations. | 27468700 | 2016 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | This meta-analysis suggested an overall weak association between the P12A polymorphism and GDM risk among East Asians. | 23054024 | 2013 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | In 1708 women of the EDEN mother-child cohort, the PPARγ Pro12Ala and C1431T polymorphisms were genotyped and analyzed in association with maternal prepregnancy body mass index, obesity before pregnancy, and gestational diabetes, separately and also combined in haplotypes. | 21795447 | 2011 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | We hypothesized that interaction between PPARG2 Pro12Ala and variants in the promoter region of HNF4A are associated with type 2 diabetes-related quantitative traits in Mexican-American families of a proband with previous gestational diabetes. | 18162503 | 2008 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | The other polymorphisms studied were not significantly associated with gestational diabetes mellitus (ADIPOQ +276G > T: 1.17 [1.01-1.36], p = 0.039 [Pc = 0.23]; PPARG Pro12Ala: 1.06 [0.87-1.29], p = 0.53; PPARGC1A Gly482Ser: 0.96 [0.83-1.10], p = 0.54; FOXC2 -512C > T: 1.01 [0.87-1.16], p = 0.94; and ADRB3 Trp64Arg: 1.22 [0.95-1.56], p = 0.12). | 17342473 | 2007 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | There were no significant differences in the frequency of the insulin gene variable number of tandem repeat ( INS VNTR) alleles and genotypes or the peroxisome proliferator-activated receptor-gamma 2 ( PPAR gamma 2-Pro12Ala) polymorphism between the women with gestational diabetes and the control women either in Arabian or in Scandinavian women. | 15095040 | 2004 | |||||
Gestational Diabetes
|
0.100 | GeneticVariation | BEFREE | We have tested whether the Pro12Ala variant of the peroxisome proliferator-activated receptor (PPAR)-gamma nuclear receptor involved in thiazolidinedione (TZD) action accounted for the failure of troglitazone to increase insulin sensitivity in nondiabetic Hispanic women with previous gestational diabetes treated in the Troglitazone in Prevention of Diabetes (TRIPOD) study. | 15161789 | 2004 |