|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR (C677T, A1298C) and MTRR A66G polymorphisms were found to be protector factors for NTD fetuses in the mother group.
|
31238314 |
2019 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that rs2236225 of MTHFD1 gene, rs1801133 of MTHFR gene and rs1801394 of MTRR gene were associated with NTDs in Han population of Northern China.
|
29392422 |
2018 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, we found that maternal MTHFR C677T polymorphism (OR(TvsC) =1.20; 95% CI = 1.13-1.28) and MTRR A66G polymorphism (OR(GvsA) = 1.21; 95% CI = 0.98-1.49) were risk factors for producing offspring with NTD but maternal MTHFR A1298C polymorphism (OR(CvsA) = 0.91; 95% CI = 0.78-1.07) was not associated with NTD risk.
|
25005003 |
2015 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The further meta-analysis enhance that MTRR 66A>G was connected with the susceptibility of NTDs widely.
|
26334892 |
2015 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analysis indicated that MTRR A66G polymorphism, but not MTR A2756G, is significantly associated with maternal risk for NTDs in Caucasians.
|
23266814 |
2013 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analyses indicate that MTR A2756G and MTRR A66G polymorphism are not associated with NTD risks in Caucasian children.
|
23425389 |
2013 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we found no significant effects of MTHFR A1298C, MTR A2756G, MTRR A66G in risk of NTDs in dominant, recessive or in allelic models.
|
23593147 |
2013 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the role of four parental folate pathway single nucleotide polymorphisms (SNPs) i.e., methylene tetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase reductase (MTRR) 66A>G and glutamate carboxypeptidase (GCP) II 1561C>T on susceptibility to neural tube defects (NTDs) in 50 couples with NTD offspring and 80 couples with normal pregnancy outcome.
|
20047525 |
2010 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analyses were conducted to set the results of the case-control study in the context of eligible literature on the relation between the MTRR 66A>G variant and NTD risk.
|
17024475 |
2006 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association was found between NTD</span>s and I22M </span>in mothers (p = 0.16, OR1.14 [0.95-1.38], n = 447) or cases (p = 0.13, OR1.15 [0.96-1.38], n = 470) compared to controls (n = 476).
|
15979034 |
2005 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR 677C-->T polymorphism was shown to represent a risk factor in NTD cases (CC v CT+TT odds ratio (OR) 2.03 [95% confidence interval (CI) 1.09, 3.79] p = 0.025) and the MTRR 66A-->G</span> polymorphism was shown to exert a protective effect in NTD cases (AA v AG+GG OR 0.31 [95% CI 0.10, 0.94] p = 0.04).
|
15060097 |
2004 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
We detected MTR A2756G and MTRR A66G polymorphisms using PCR-RFLP analysis in a group of NTD infants, their mothers and normal controls.
|
12649067 |
2003 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
This polymorphorism, 66A-->G (I22M), has an allele frequency of 0.51 and increases NTD risk when cobalamin status is low or when the MTHFR mutant genotype is present.
|
10444342 |
1999 |