|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR (C677T, A1298C) and MTRR A66G polymorphisms were found to be protector factors for NTD fetuses in the mother group.
|
31238314 |
2019 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our overall analyses suggested that <i>MTRR</i> rs1801394, <i>MTRR</i> rs1532268, <i>MTHFR</i> rs1801131 and <i>MTHFR</i> rs1801133 polymorphisms were all significantly associated with the risk of CHD in certain genetic models.
|
30333252 |
2018 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that rs2236225 of MTHFD1 gene, rs1801133 of MTHFR gene and rs1801394 of MTRR gene were associated with NTDs in Han population of Northern China.
|
29392422 |
2018 |
|
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study aim to investigate MTHFR C677T, MTHFR A1298C, RFC1 A80G, MTR A2756G, CBS 844ins68, MTRR A66G polymorphisms in Down syndrome (DS) parents.
|
29130768 |
2017 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Also, MTRR A66G and C524T polymorphisms were associated with a higher CHD risk in the homozygote comparison of wild and mutant genotypes and also in heterozygote and mutant comparison.
|
28778621 |
2017 |
|
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study aim to investigate MTHFR C677T, MTHFR A1298C, RFC1 A80G, MTR A2756G, CBS 844ins68, MTRR A66G polymorphisms in Down syndrome (DS) parents.
|
29130768 |
2017 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, we found that maternal MTHFR C677T polymorphism (OR(TvsC) =1.20; 95% CI = 1.13-1.28) and MTRR A66G polymorphism (OR(GvsA) = 1.21; 95% CI = 0.98-1.49) were risk factors for producing offspring with NTD but maternal MTHFR A1298C polymorphism (OR(CvsA) = 0.91; 95% CI = 0.78-1.07) was not associated with NTD risk.
|
25005003 |
2015 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The further meta-analysis enhance that MTRR 66A>G was connected with the susceptibility of NTDs widely.
|
26334892 |
2015 |
|
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was evidence for an association between the MTRR c.66A>G</span> (rs1801394) polymorphism and maternal risk for DS.
|
25544792 |
2014 |
|
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was evidence for an association between the MTRR c.66A>G</span> (rs1801394) polymorphism and maternal risk for DS.
|
25544792 |
2014 |
|
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, present data suggest that the MTRR c.66A>G polymorphism represents a risk factor for the birth of a child with DS among white Caucasian women.
|
24965145 |
2014 |
|
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, present data suggest that the MTRR c.66A>G polymorphism represents a risk factor for the birth of a child with DS among white Caucasian women.
|
24965145 |
2014 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evidence is mounting for the association between MTRR A66G (rs1801394)/MTR A2756G (rs1805087) and the CHD risk, but results are controversial.
|
24595101 |
2014 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results showed that MTRR A66G polymorphism was associated with a higher CHD risk in the allele comparison (G vs A: OR 1.163; 95 % CI 1.016-1.330; P heterogeneity = 0.004), the homozygote comparison (GG vs AA: OR 1.332; 95 % CI 1.020-1.740; P heterogeneity = 0.035), and the dominant model (GG/AG vs AA: OR 1.218; 95 % CI 1.001-1.482; P heterogeneity = 0.001).
|
24913415 |
2014 |
|
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that maternal MTRR 66A>G polymorphism is associated with an increased risk of having a DS child.
|
23094987 |
2013 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analysis indicated that MTRR A66G polymorphism, but not MTR A2756G, is significantly associated with maternal risk for NTDs in Caucasians.
|
23266814 |
2013 |
|
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the relationship between maternal methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, reduced folate carrier 1 A80G and cystathionine β-synthase 844ins68 polymorphisms and the risk of having a DS offspring.
|
24068460 |
2013 |
|
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the relationship between maternal methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, reduced folate carrier 1 A80G and cystathionine β-synthase 844ins68 polymorphisms and the risk of having a DS offspring.
|
24068460 |
2013 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analyses indicate that MTR A2756G and MTRR A66G polymorphism are not associated with NTD risks in Caucasian children.
|
23425389 |
2013 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we found no significant effects of MTHFR A1298C, MTR A2756G, MTRR A66G in risk of NTDs in dominant, recessive or in allelic models.
|
23593147 |
2013 |
|
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that maternal MTRR 66A>G polymorphism is associated with an increased risk of having a DS child.
|
23094987 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that MTR A2756G polymorphism, but not MTRR A66G and MTHFR A1298C, is associated with risk of CHD for Europeans.
|
21780915 |
2012 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate gene polymorphisms MTR A2756G, MTRR A66G, and BHMT G742A and risk for coronary artery disease: a meta-analysis.
|
22339686 |
2012 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, MTRR A66G and C524T polymorphisms are associated with increased risk of CHDs.
|
22057956 |
2011 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the role of four parental folate pathway single nucleotide polymorphisms (SNPs) i.e., methylene tetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase reductase (MTRR) 66A>G and glutamate carboxypeptidase (GCP) II 1561C>T on susceptibility to neural tube defects (NTDs) in 50 couples with NTD offspring and 80 couples with normal pregnancy outcome.
|
20047525 |
2010 |