|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a combined French-Sardinian study of GCR , there is an association of Gly 40 Ser mutation with T2DM, confirmed by a UK study but not by others.
|
15931615 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results show that the Gly40Ser mutation in the glucagon receptor gene is not associated with type 2 diabetes in a Brazilian population.
|
11961492 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results demonstrate a strong genetic heterogeneity among the ethnic group and suggest that the Gly40Ser mutation of the glucagon receptor gene plays little role, if any, in the pathogenesis of type 2 diabetes and essential hypertension in the Taiwanese population.
|
10090412 |
1999 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the frequency of the Gly40Ser polymorphism in NIDDM observed in France is not confirmed in our population, this genetic variance is also evident in Germany.
|
10510728 |
1999 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our results indicate that the Gly40Ser variation is not associated with NIDDM in the Sardinian population and that its frequency varies in different parts of Sardinia.
|
9028723 |
1997 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that Gly40Ser polymorphism of the GCG-R gene is not associated with NIDDM in the Russian population and point to the genetic heterogeneity of NIDDM in different ethnic groups.
|
9285210 |
1997 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Restricted geographical extension of the association of a glucagon receptor gene mutation (Gly40Ser) with non-insulin-dependent diabetes mellitus.
|
8858207 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have previously reported that a single heterozygous missense mutation in exon 2 of the glucagon receptor gene, which changes a glycine to a serine (Gly40Ser), is associated with NIDDM in a French population.
|
8635644 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the Gly40-Ser mutation does not play an important role in the pathogenesis of NIDDM in Japanese patients.
|
8879960 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Absence of association between the Gly40-->Ser mutation in the human glucagon receptor and Japanese patients with non-insulin-dependent diabetes mellitus or impaired glucose tolerance.
|
8931690 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, subtypes of typical NIDDM were suggested based on missense mutations of mitochondrial DNA [tRNALeu(UUR)] and the glucagon receptor gene (Gly40Ser).
|
8732719 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
None of the Japanese diabetic patients showed Gly40Ser mutation and the association of this mutation with NIDDM was significantly different (p < 4.10(-5) vs French, p < 3.10(-6) vs Sardinian by Fisher's exact test).
|
7589886 |
1995 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, the data do not support the suggested involvement of the Gly40Ser polymorphism in impaired glucose tolerance and the hypothesis of an association between NIDDM and the glucagon receptor gene in this population.
|
8690179 |
1995 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
We conclude that the Gly40Ser polymorphism of the GCGR gene is associated with higher risk of hypertension and with enhanced proximal tubular sodium reabsorption, a factor possibly contributing to hypertension in this group.
|
11692154 |
2001 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Gly40Ser polymorphism was not significantly associated with hypertension in the whole study population, although the frequency of 40Ser carriers in hypertensive subjects was double that in normotensive subjects (3.1% in hypertensives versus 1.5%; P=0.087).
|
10406817 |
1999 |
|
Essential Hypertension
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results demonstrate a strong genetic heterogeneity among the ethnic group and suggest that the Gly40Ser mutation of the glucagon receptor gene plays little role, if any, in the pathogenesis of type 2 diabetes and essential hypertension in the Taiwanese population.
|
10090412 |
1999 |
|
Essential Hypertension
|
|
0.030 |
GeneticVariation
|
BEFREE |
Glucagon receptor gene mutation (Gly40Ser) in human essential hypertension: the PEGASE study.
|
10406817 |
1999 |
|
Essential Hypertension
|
|
0.030 |
GeneticVariation
|
BEFREE |
1.Previous glucagon receptor gene (GCGR) studies have shown a Gly40Ser mutation to be more prevalent in essential hypertension and to affect glucagon binding affinity to its receptor.
|
9673441 |
1998 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
No association of the Gly40Ser variant with hypertension was seen in this large population.
|
9325468 |
1997 |
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
A total of 348 unrelated Japanese subjects (220 with NIDDM, 53 with impaired glucose tolerance (IGT) and 75 normal subjects) were screened for the presence of the Gly40-Ser mutation.
|
8879960 |
1996 |
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Absence of association between the Gly40-->Ser mutation in the human glucagon receptor and Japanese patients with non-insulin-dependent diabetes mellitus or impaired glucose tolerance.
|
8931690 |
1996 |
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Taken together, the data do not support the suggested involvement of the Gly40Ser polymorphism in impaired glucose tolerance and the hypothesis of an association between NIDDM and the glucagon receptor gene in this population.
|
8690179 |
1995 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
Patients with diabetes and carriers of Gly40Ser showed basal C-peptide levels significantly lower than noncarriers (0.70 ng/mL versus 1.50 ng/mL, p = 0.008).
|
11961492 |
2002 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.
|
7589886 |
1995 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with diabetes and carriers of Gly40Ser showed basal C-peptide levels significantly lower than noncarriers (0.70 ng/mL versus 1.50 ng/mL, p = 0.008).
|
11961492 |
2002 |