rs1801516, ATM

N. diseases: 39
Disease: Primary malignant neoplasm ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE ATM rs1801516 polymorphism is not associated with overall cancer risk in total population. 30384829 2018
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Single Nucleotide Polymorphism rs1801516 in Ataxia Telangiectasia-Mutated Gene Predicts Late Fibrosis in Cancer Patients After Radiotherapy: A PRISMA-Compliant Systematic Review and Meta-Analysis. 27057881 2016
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Based on the results, we propose a cancer risk-modifying effect for the ATM 5557G-->A, IVS38-8T-->C composite allele. 15756685 2005
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE The IVS24-9 T/(-T), IVS38-8 T/C, 5557 G/A composite genotype alone or in combination with certain genetic background and/or environmental factors, could modify the cancer risk by increasing genetic instability or by altering the effect of the normal DNA damage response. 18433505 2008
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Meta-analysis of associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and adverse effects of cancer radiotherapy. 25605158 2014
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Our meta-analyses confirmed the presence of a gene-environment interaction between the rs1801516 polymorphism and radiation exposure in carcinogenesis, whereas no association was found between the rs1801516 polymorphism and cancer risk for individuals without radiation exposure. 27764772 2016