Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE ATM rs1801516 polymorphism is not associated with overall cancer risk in total population. 30384829 2018
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Single Nucleotide Polymorphism rs1801516 in Ataxia Telangiectasia-Mutated Gene Predicts Late Fibrosis in Cancer Patients After Radiotherapy: A PRISMA-Compliant Systematic Review and Meta-Analysis. 27057881 2016
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Our meta-analyses confirmed the presence of a gene-environment interaction between the rs1801516 polymorphism and radiation exposure in carcinogenesis, whereas no association was found between the rs1801516 polymorphism and cancer risk for individuals without radiation exposure. 27764772 2016
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Meta-analysis of associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and adverse effects of cancer radiotherapy. 25605158 2014
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE The IVS24-9 T/(-T), IVS38-8 T/C, 5557 G/A composite genotype alone or in combination with certain genetic background and/or environmental factors, could modify the cancer risk by increasing genetic instability or by altering the effect of the normal DNA damage response. 18433505 2008
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Based on the results, we propose a cancer risk-modifying effect for the ATM 5557G-->A, IVS38-8T-->C composite allele. 15756685 2005